EIF4EBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= EIF4EBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF4EBP1
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 4E binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1978|1978]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13541|Q13541]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF4EBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF4EBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602223|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|eIF 4EBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cap-independent translational initiation of linear mRNA|
|cap-independent translational initiation|
|IRES-dependent translational initiation of linear mRNA|
|eukaryotic initiation factor 4E binding|
|translation repressor activity|
|postsynaptic cytosol|
|negative regulation of translational initiation|
|TOR signaling|
|cellular response to dexamethasone stimulus|
|cytoplasmic translational initiation|
|protein phosphatase 2A binding|
|response to dexamethasone|
|response to amino acid starvation|
|response to ischemia|
|cellular response to glucocorticoid stimulus|
|cellular response to corticosteroid stimulus|
|cytoplasmic translation|
|regulation of translational initiation|
|insulin receptor signaling pathway|
|cellular response to ketone|
|response to antineoplastic agent|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|response to ethanol|
|negative regulation of translation|
|negative regulation of protein complex assembly|
|translational initiation|
|response to glucocorticoid|
|negative regulation of cellular amide metabolic process|
|positive regulation of mitotic cell cycle|
|response to corticosteroid|
|cellular response to insulin stimulus|
|lung development|
|respiratory tube development|
|cellular response to xenobiotic stimulus|
|cellular response to hypoxia|
|cellular response to steroid hormone stimulus|
|response to ketone|
|response to starvation|
|respiratory system development|
|cellular response to decreased oxygen levels|
|cellular response to oxygen levels|
|response to insulin|
|response to alcohol|
|cellular response to peptide hormone stimulus|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|response to xenobiotic stimulus|
|response to antibiotic|
|cellular response to peptide|
|response to steroid hormone|
|response to hypoxia|
|glutamatergic synapse|
|regulation of translation|
|response to decreased oxygen levels|
|positive regulation of cell cycle|
|response to oxygen levels|
|translation|
|response to peptide hormone|
|regulation of cellular amide metabolic process|
|cellular response to drug|
|peptide biosynthetic process|
|regulation of protein complex assembly|
|response to peptide|
|response to nutrient levels|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cellular response to lipid|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|protein-containing complex|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|cellular response to nitrogen compound|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|enzyme linked receptor protein signaling pathway|
|cellular amide metabolic process|
|tube development|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|regulation of cellular component biogenesis|
|cell cycle process|
|response to organonitrogen compound|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|response to abiotic stimulus|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.79|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.3|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|3.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7682
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF4EBP1 Expression in NALM6 Cells: 5.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>