EIF4ENIF1 [The Human Chemical-Genetic Interaction Map Project]

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======= EIF4ENIF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF4ENIF1
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 4E nuclear import factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56478|56478]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRA8|Q9NRA8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF4ENIF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF4ENIF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607445|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism. {ECO:0000269|PubMed:10856257}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EIF4E-T|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear export signal receptor activity|
|P-body|
|PML body|
|negative regulation of translation|
|stem cell population maintenance|
|maintenance of cell number|
|negative regulation of cellular amide metabolic process|
|nuclear export|
|mRNA binding|
|negative regulation of neuron differentiation|
|nucleocytoplasmic transport|
|nuclear transport|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|negative regulation of cell development|
|regulation of translation|
|nuclear speck|
|regulation of cellular amide metabolic process|
|posttranscriptional regulation of gene expression|
|regulation of neuron differentiation|
|intracellular membrane-bounded organelle|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of multicellular organismal process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|generation of neurons|
|peptide transport|
|negative regulation of biosynthetic process|
|amide transport|
|establishment of protein localization|
|neurogenesis|
|negative regulation of gene expression|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.74|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.92|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.96|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.36|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.38|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3988
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF4ENIF1 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>