EIF6 [The Human Chemical-Genetic Interaction Map Project]

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======= EIF6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF6
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3692|3692]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56537|P56537]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602912|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS- dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA- induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity). {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:21536732}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|eIF-6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|assembly of large subunit precursor of preribosome|
|lamin filament|
|mature ribosome assembly|
|negative regulation of translation, ncRNA-mediated|
|miRNA mediated inhibition of translation|
|ribosomal large subunit binding|
|regulation of translation, ncRNA-mediated|
|ribosomal subunit export from nucleus|
|ribosome localization|
|rRNA-containing ribonucleoprotein complex export from nucleus|
|preribosome, large subunit precursor|
|regulation of fatty acid biosynthetic process|
|gene silencing by miRNA|
|translation initiation factor activity|
|regulation of megakaryocyte differentiation|
|ribosome binding|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|ribosome assembly|
|ribosomal large subunit biogenesis|
|regulation of glycolytic process|
|regulation of fatty acid metabolic process|
|gene silencing by RNA|
|regulation of carbohydrate catabolic process|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|positive regulation of translation|
|RNA export from nucleus|
|negative regulation of translation|
|translational initiation|
|negative regulation of cellular amide metabolic process|
|protein export from nucleus|
|positive regulation of cellular amide metabolic process|
|gene silencing|
|nuclear export|
|regulation of generation of precursor metabolites and energy|
|regulation of cellular ketone metabolic process|
|regulation of reactive oxygen species metabolic process|
|regulation of lipid biosynthetic process|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|regulation of carbohydrate metabolic process|
|RNA localization|
|regulation of myeloid cell differentiation|
|response to insulin|
|ribonucleoprotein complex assembly|
|regulation of gene expression, epigenetic|
|nucleobase-containing compound transport|
|ribonucleoprotein complex subunit organization|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|ribosome biogenesis|
|regulation of translation|
|establishment of organelle localization|
|translation|
|response to peptide hormone|
|regulation of lipid metabolic process|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|regulation of small molecule metabolic process|
|regulation of hemopoiesis|
|ribonucleoprotein complex biogenesis|
|response to peptide|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|organelle localization|
|organelle assembly|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|nucleolus|
|response to hormone|
|regulation of catabolic process|
|intracellular protein transport|
|response to organonitrogen compound|
|negative regulation of cellular protein metabolic process|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.02|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.73|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.79|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.79|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.79|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.83|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.88|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.91|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.98|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.98|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.41|
|[[:human genes:c:chaf1a|CHAF1A]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 526/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|22/28|
|blood|23/28|
|bone|20/26|
|breast|23/33|
|central nervous system|38/56|
|cervix|3/4|
|colorectal|12/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|9/16|
|kidney|15/21|
|liver|14/20|
|lung|54/75|
|lymphocyte|11/16|
|ovary|21/26|
|pancreas|20/24|
|peripheral nervous system|14/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|18/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|14/22|
|urinary tract|15/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 187
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF6 Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>