ELMOD3 [The Human Chemical-Genetic Interaction Map Project]

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======= ELMOD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ELMOD3
  * **<color #00a2e8>Official Name</color>**: ELMO domain containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84173|84173]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96FG2|Q96FG2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ELMOD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ELMOD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615427|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the engulfment and cell motility family of GTPase-activating proteins that regulate Arf GTPase proteins. Members of this family are defined by a conserved engulfment and cell motility domain. In rat cochlea, the encoded protein is found in stereocilia, kinocilia and cuticular plate of developing hair cells suggesting a function for this protein in cochlear sensory cells. An allelic variant of this family has been associated with autosomal recessive nonsyndromic deafness-88 in humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ELMO CED12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|kinocilium|
|stereocilium|
|GTPase activator activity|
|cytoskeleton|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|positive regulation of hydrolase activity|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.95|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.507|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.503|
|[[:human genes:v:vasn|VASN]]|0.493|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.47|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.468|
|[[:human genes:z:znf106|ZNF106]]|0.468|
|[[:human genes:m:med17|MED17]]|0.468|
|[[:human genes:t:top1mt|TOP1MT]]|0.466|
|[[:human genes:s:ssh2|SSH2]]|0.456|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.455|
|[[:human genes:o:orc1|ORC1]]|0.453|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.447|
|[[:human genes:n:nup54|NUP54]]|0.447|
|[[:human genes:t:traip|TRAIP]]|0.443|
|[[:human genes:r:rps2|RPS2]]|0.443|
|[[:human genes:p:prpf8|PRPF8]]|0.442|
|[[:human genes:t:twistnb|TWISTNB]]|0.44|
|[[:human genes:d:dync1i2|DYNC1I2]]|0.439|
|[[:human genes:c:c14orf93|C14orf93]]|0.438|
|[[:human genes:l:lrr1|LRR1]]|0.435|
|[[:human genes:a:aqr|AQR]]|0.432|
|[[:human genes:r:rpl14|RPL14]]|0.432|
|[[:human genes:c:cbwd3|CBWD3]]|0.431|
|[[:human genes:c:cdc6|CDC6]]|0.429|
|[[:human genes:n:npipb5|NPIPB5]]|0.427|
|[[:human genes:k:kctd17|KCTD17]]|0.424|
|[[:human genes:a:akirin2|AKIRIN2]]|0.421|
|[[:human genes:f:fam86b2|FAM86B2]]|0.421|
|[[:human genes:n:nbpf10|NBPF10]]|0.42|
|[[:human genes:a:ahctf1|AHCTF1]]|0.42|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.42|
|[[:human genes:s:scaf1|SCAF1]]|0.42|
|[[:human genes:r:rps12|RPS12]]|0.419|
|[[:human genes:a:ankle1|ANKLE1]]|0.419|
|[[:human genes:c:cbwd5|CBWD5]]|0.416|
|[[:human genes:m:myo1h|MYO1H]]|0.416|
|[[:human genes:g:golga6a|GOLGA6A]]|0.414|
|[[:human genes:p:pcf11|PCF11]]|0.414|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.414|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.414|
|[[:human genes:m:myt1|MYT1]]|0.414|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.413|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.413|
|[[:human genes:b:bysl|BYSL]]|0.413|
|[[:human genes:n:nup133|NUP133]]|0.413|
|[[:human genes:p:pola2|POLA2]]|0.412|
|[[:human genes:c:chd4|CHD4]]|0.411|
|[[:human genes:d:ddx56|DDX56]]|0.411|
|[[:human genes:r:rbm39|RBM39]]|0.41|
|[[:human genes:r:rrn3|RRN3]]|0.408|
|[[:human genes:c:cmya5|CMYA5]]|0.405|
|[[:human genes:r:rps7|RPS7]]|0.404|
|[[:human genes:f:fancm|FANCM]]|0.402|
|[[:human genes:c:cbwd6|CBWD6]]|0.4|
|[[:human genes:c:cdc73|CDC73]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2286
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ELMOD3 Expression in NALM6 Cells: 4.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>