EMC1 [The Human Chemical-Genetic Interaction Map Project]

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======= EMC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EMC1
  * **<color #00a2e8>Official Name</color>**: ER membrane protein complex subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23065|23065]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N766|Q8N766]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EMC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EMC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616846|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a single-pass type I transmembrane protein, which is a subunit of the endoplasmic reticulum membrane protein complex (EMC). Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1620|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ER membrane protein complex|
|protein folding in endoplasmic reticulum|
|protein folding|
|protein-containing complex|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-2.38|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.91|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.86|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.83|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.76|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.76|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.74|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mmgt1|MMGT1]]|0.575|
|[[:human genes:e:emc2|EMC2]]|0.512|
|[[:human genes:e:emc3|EMC3]]|0.475|
|[[:human genes:e:emc4|EMC4]]|0.453|
|[[:human genes:e:emc6|EMC6]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 222/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|11/28|
|bone|10/26|
|breast|6/33|
|central nervous system|14/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|4/16|
|kidney|13/21|
|liver|2/20|
|lung|24/75|
|lymphocyte|4/16|
|ovary|6/26|
|pancreas|12/24|
|peripheral nervous system|2/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|8/24|
|soft tissue|3/9|
|thyroid|2/2|
|upper aerodigestive|9/22|
|urinary tract|10/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1875
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EMC1 Expression in NALM6 Cells: 7.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>