ENAM [The Human Chemical-Genetic Interaction Map Project]

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======= ENAM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ENAM
  * **<color #00a2e8>Official Name</color>**: enamelin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10117|10117]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRM1|Q9NRM1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ENAM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ENAM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606585|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene encodes the largest protein in the enamel matrix of developing teeth. The protein is involved in the mineralization and structural organization of enamel. Defects in this gene result in amelogenesis imperfect type 1C.[provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. {ECO:0000250|UniProtKB:O97939}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ameloblast differentiation|
|positive regulation of enamel mineralization|
|positive regulation of odontogenesis of dentin-containing tooth|
|regulation of enamel mineralization|
|positive regulation of tooth mineralization|
|structural constituent of tooth enamel|
|regulation of tooth mineralization|
|positive regulation of odontogenesis|
|regulation of odontogenesis of dentin-containing tooth|
|amelogenesis|
|regulation of odontogenesis|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|positive regulation of animal organ morphogenesis|
|odontogenesis of dentin-containing tooth|
|biomineralization|
|biomineral tissue development|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|columnar/cuboidal epithelial cell differentiation|
|odontogenesis|
|extracellular matrix|
|regulation of animal organ morphogenesis|
|endoplasmic reticulum lumen|
|post-translational protein modification|
|regulation of cell morphogenesis|
|epithelial cell differentiation|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|positive regulation of developmental process|
|positive regulation of multicellular organismal process|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11777
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ENAM Expression in NALM6 Cells: -0.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>