ENO2 [The Human Chemical-Genetic Interaction Map Project]

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======= ENO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ENO2
  * **<color #00a2e8>Official Name</color>**: enolase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2026|2026]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09104|P09104]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ENO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ENO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131360|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Enolase N|
|Enolase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphopyruvate hydratase complex|
|phosphopyruvate hydratase activity|
|glucose catabolic process to pyruvate|
|NADH regeneration|
|canonical glycolysis|
|glycolytic process through glucose-6-phosphate|
|glycolytic process through fructose-6-phosphate|
|glucose catabolic process|
|NADH metabolic process|
|glycolytic process|
|ATP generation from ADP|
|gluconeogenesis|
|NAD metabolic process|
|hexose biosynthetic process|
|photoreceptor inner segment|
|ADP metabolic process|
|hexose catabolic process|
|monosaccharide biosynthetic process|
|nucleoside diphosphate phosphorylation|
|nucleotide phosphorylation|
|monosaccharide catabolic process|
|purine ribonucleoside diphosphate metabolic process|
|purine nucleoside diphosphate metabolic process|
|ribonucleoside diphosphate metabolic process|
|pyruvate metabolic process|
|nucleoside diphosphate metabolic process|
|glucose metabolic process|
|carbohydrate catabolic process|
|carbohydrate biosynthetic process|
|perikaryon|
|hexose metabolic process|
|monosaccharide metabolic process|
|ATP metabolic process|
|magnesium ion binding|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|carbohydrate metabolic process|
|monocarboxylic acid metabolic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|phosphorylation|
|extracellular space|
|small molecule metabolic process|
|organic substance catabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.61|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.11|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.06|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.92|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.82|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.75|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.94|
|[[:results:exp453|B02 10μM R08 exp453]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10007
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ENO2 Expression in NALM6 Cells: 4.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>