ENPP2 [The Human Chemical-Genetic Interaction Map Project]

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======= ENPP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ENPP2
  * **<color #00a2e8>Official Name</color>**: ectonucleotide pyrophosphatase/phosphodiesterase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5168|5168]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13822|Q13822]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ENPP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ENPP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601060|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Phosphodiest|
|Somatomedin B|
|Endonuclease NS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alkylglycerophosphoethanolamine phosphodiesterase activity|
|nucleotide diphosphatase activity|
|phosphatidylcholine catabolic process|
|phosphodiesterase I activity|
|positive regulation of lamellipodium morphogenesis|
|regulation of lamellipodium morphogenesis|
|polysaccharide binding|
|glycerophospholipid catabolic process|
|lysophospholipase activity|
|positive regulation of lamellipodium organization|
|phospholipid catabolic process|
|regulation of lamellipodium organization|
|scavenger receptor activity|
|glycerolipid catabolic process|
|phosphatidylcholine metabolic process|
|hydrolase activity|
|organophosphate catabolic process|
|positive regulation of epithelial cell migration|
|positive regulation of peptidyl-tyrosine phosphorylation|
|ammonium ion metabolic process|
|nucleic acid binding|
|cellular lipid catabolic process|
|regulation of epithelial cell migration|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of angiogenesis|
|lipid catabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|glycerophospholipid metabolic process|
|regulation of vasculature development|
|transcription factor binding|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|positive regulation of cell projection organization|
|regulation of cell morphogenesis|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|endocytosis|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|calcium ion binding|
|zinc ion binding|
|regulation of cell migration|
|organophosphate metabolic process|
|regulation of cell motility|
|cellular lipid metabolic process|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|localization of cell|
|cell motility|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of protein modification process|
|locomotion|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.78|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.88|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.87|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.79|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.87|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.93|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.663|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18391
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ENPP2 Expression in NALM6 Cells: 5.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>