EPB41L3 [The Human Chemical-Genetic Interaction Map Project]

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======= EPB41L3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPB41L3
  * **<color #00a2e8>Official Name</color>**: erythrocyte membrane protein band 4.1 like 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23136|23136]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2J2|Q9Y2J2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPB41L3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPB41L3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605331|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N- methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16420693, ECO:0000269|PubMed:9892180}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FERM C|
|FA|
|4 1 CTD|
|SAB|
|FERM N|
|FERM M|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to paranode region of axon|
|protein localization to juxtaparanode region of axon|
|paranodal junction assembly|
|protein localization to axon|
|cytoskeletal anchoring at plasma membrane|
|juxtaparanode region of axon|
|paranode region of axon|
|myelin maintenance|
|axolemma|
|myelin assembly|
|cortical actin cytoskeleton organization|
|cortical cytoskeleton organization|
|maintenance of protein location in cell|
|plasma membrane organization|
|maintenance of location in cell|
|structural constituent of cytoskeleton|
|cellular component assembly involved in morphogenesis|
|cell-cell junction assembly|
|myelination|
|maintenance of protein location|
|axon ensheathment|
|ensheathment of neurons|
|actomyosin structure organization|
|cell-cell junction organization|
|regulation of cell shape|
|maintenance of location|
|cell junction assembly|
|cell-cell junction|
|protein localization to plasma membrane|
|cell junction organization|
|protein localization to cell periphery|
|postsynaptic density|
|actin binding|
|cytoskeleton|
|regulation of cell growth|
|endomembrane system organization|
|neuron projection morphogenesis|
|protein localization to membrane|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|cell part morphogenesis|
|actin filament-based process|
|neuron projection development|
|regulation of growth|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|membrane organization|
|anatomical structure formation involved in morphogenesis|
|apoptotic process|
|neuron differentiation|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|generation of neurons|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|-2.17|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.7|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.7|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.89|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2581
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPB41L3 Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>