EPHA5 [The Human Chemical-Genetic Interaction Map Project]

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======= EPHA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EPHA5
  * **<color #00a2e8>Official Name</color>**: EPH receptor A5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2044|2044]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54756|P54756]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EPHA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EPHA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600004|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose- stimulated insulin secretion (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM 1|
|Pkinase Tyr|
|SAM 2|
|Ephrin lbd|
|Pkinase|
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ephrin receptor activity|
|GPI-linked ephrin receptor activity|
|transmembrane-ephrin receptor activity|
|positive regulation of CREB transcription factor activity|
|transmembrane receptor protein tyrosine kinase activity|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|rough endoplasmic reticulum|
|hippocampus development|
|ephrin receptor signaling pathway|
|limbic system development|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|pallium development|
|regulation of insulin secretion|
|receptor complex|
|regulation of peptide hormone secretion|
|telencephalon development|
|axon guidance|
|positive regulation of DNA-binding transcription factor activity|
|neuron projection guidance|
|regulation of hormone secretion|
|axon|
|neuron projection|
|second-messenger-mediated signaling|
|regulation of actin cytoskeleton organization|
|axonogenesis|
|neuronal cell body|
|forebrain development|
|regulation of actin filament-based process|
|external side of plasma membrane|
|axon development|
|dendrite|
|regulation of DNA-binding transcription factor activity|
|cell morphogenesis involved in neuron differentiation|
|regulation of protein secretion|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of peptide secretion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of hormone levels|
|regulation of cytoskeleton organization|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|neuron projection development|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|head development|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|protein phosphorylation|
|central nervous system development|
|neuron differentiation|
|regulation of protein localization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|integral component of plasma membrane|
|ATP binding|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.95|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14570
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.38 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EPHA5 Expression in NALM6 Cells: -2.38'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>