ESPL1 [The Human Chemical-Genetic Interaction Map Project]

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======= ESPL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ESPL1
  * **<color #00a2e8>Official Name</color>**: extra spindle pole bodies like 1, separase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9700|9700]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14674|Q14674]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ESPL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ESPL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604143|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase C50|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of sister chromatid cohesion|
|positive regulation of mitotic metaphase/anaphase transition|
|positive regulation of mitotic sister chromatid separation|
|positive regulation of metaphase/anaphase transition of cell cycle|
|positive regulation of chromosome separation|
|meiotic spindle organization|
|positive regulation of mitotic sister chromatid segregation|
|regulation of sister chromatid cohesion|
|meiotic chromosome separation|
|positive regulation of chromosome segregation|
|cysteine-type peptidase activity|
|chromosome separation|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|establishment of mitotic spindle localization|
|establishment of spindle localization|
|catalytic activity|
|spindle localization|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|positive regulation of mitotic nuclear division|
|homologous chromosome segregation|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|positive regulation of nuclear division|
|mitotic cytokinesis|
|regulation of mitotic sister chromatid segregation|
|positive regulation of mitotic cell cycle phase transition|
|mitotic spindle|
|regulation of sister chromatid segregation|
|meiotic chromosome segregation|
|cysteine-type endopeptidase activity|
|positive regulation of cell cycle phase transition|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|regulation of chromosome segregation|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|meiosis I|
|meiosis I cell cycle process|
|negative regulation of chromosome organization|
|sister chromatid segregation|
|mitotic nuclear division|
|positive regulation of mitotic cell cycle|
|meiotic nuclear division|
|spindle organization|
|meiotic cell cycle process|
|regulation of mitotic nuclear division|
|positive regulation of chromosome organization|
|regulation of nuclear division|
|nuclear chromosome segregation|
|meiotic cell cycle|
|chromosome segregation|
|nuclear division|
|positive regulation of cell cycle process|
|organelle fission|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|establishment of organelle localization|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|negative regulation of cell cycle|
|organelle localization|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|apoptotic process|
|cell cycle process|
|programmed cell death|
|chromosome organization|
|cell death|
|cytoskeleton organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-3.03|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.83|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.75|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.7|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.43|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.38|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.37|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.33|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.31|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-2.22|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.2|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.17|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.16|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.11|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.1|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.1|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.06|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-2.04|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.03|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-2.01|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.97|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.96|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.95|
|[[:results:exp539|42°C R08 exp539]]|-1.92|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.89|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.89|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.87|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.86|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.85|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.82|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.79|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.79|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.75|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.71|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.75|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.8|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.8|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.94|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.04|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|2.08|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|2.25|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|2.49|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|2.63|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|3.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cbwd5|CBWD5]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 724/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|6/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 373
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ESPL1 Expression in NALM6 Cells: 7.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>