ETFDH [The Human Chemical-Genetic Interaction Map Project]

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======= ETFDH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ETFDH
  * **<color #00a2e8>Official Name</color>**: electron transfer flavoprotein dehydrogenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2110|2110]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16134|Q16134]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ETFDH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ETFDH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/231675|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the electron-transfer system in mitochondria and is essential for electron transfer from a number of mitochondrial flavin-containing dehydrogenases to the main respiratory chain. Mutations in this gene are associated with glutaric acidemia. Alternatively spliced transcript variants that encode distinct isoforms have been observed. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accepts electrons from ETF and reduces ubiquinone.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thi4|
|ETF QO|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|
|electron-transferring-flavoprotein dehydrogenase activity|
|ubiquinone binding|
|fatty acid beta-oxidation using acyl-CoA dehydrogenase|
|quinone binding|
|integral component of mitochondrial inner membrane|
|4 iron, 4 sulfur cluster binding|
|fatty acid beta-oxidation|
|flavin adenine dinucleotide binding|
|electron transfer activity|
|fatty acid oxidation|
|lipid oxidation|
|fatty acid catabolic process|
|mitochondrial membrane|
|respiratory electron transport chain|
|monocarboxylic acid catabolic process|
|oxidoreductase activity|
|cellular respiration|
|electron transport chain|
|cellular lipid catabolic process|
|lipid modification|
|energy derivation by oxidation of organic compounds|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|lipid catabolic process|
|fatty acid metabolic process|
|mitochondrial matrix|
|response to oxidative stress|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|monocarboxylic acid metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-3.54|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.43|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.3|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-2.24|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.06|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.95|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.83|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.78|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-1.7|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.74|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.74|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.77|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.81|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.81|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.83|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.83|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.93|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.93|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.99|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.1|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.16|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.16|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.23|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.25|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.37|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|3.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.451|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19030
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ETFDH Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>