ETV3 [The Human Chemical-Genetic Interaction Map Project]

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======= ETV3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ETV3
  * **<color #00a2e8>Official Name</color>**: ETS variant transcription factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2117|2117]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41162|P41162]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ETV3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ETV3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164873|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ets|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II transcription repressor complex|
|DEAD/H-box RNA helicase binding|
|response to granulocyte macrophage colony-stimulating factor|
|cellular response to granulocyte macrophage colony-stimulating factor stimulus|
|nuclear chromatin|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|negative regulation of cell population proliferation|
|molecular function|
|negative regulation of transcription by RNA polymerase II|
|cellular response to cytokine stimulus|
|response to cytokine|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2.47|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.79|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.78|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.78|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.8|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.84|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.9|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.68|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.432|
|[[:human genes:p:polr2j3|POLR2J3]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4320
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ETV3 Expression in NALM6 Cells: 5.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>