ETV5 [The Human Chemical-Genetic Interaction Map Project]

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======= ETV5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ETV5
  * **<color #00a2e8>Official Name</color>**: ETS variant transcription factor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2119|2119]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41161|P41161]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ETV5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ETV5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601600|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'. {ECO:0000269|PubMed:8152800}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ETS PEA3 N|
|Ets|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|germline stem cell asymmetric division|
|male germ-line stem cell asymmetric division|
|germ-line stem cell division|
|regulation of branching involved in mammary gland duct morphogenesis|
|skeletal muscle acetylcholine-gated channel clustering|
|asymmetric stem cell division|
|positive regulation of glial cell proliferation|
|asymmetric cell division|
|postsynaptic membrane organization|
|regulation of glial cell proliferation|
|neuromuscular synaptic transmission|
|stem cell division|
|neuromuscular junction development|
|receptor clustering|
|regulation of morphogenesis of a branching structure|
|positive regulation of gliogenesis|
|localization within membrane|
|postsynapse organization|
|regulation of gliogenesis|
|regulation of morphogenesis of an epithelium|
|locomotory behavior|
|transcription regulatory region DNA binding|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|cellular response to oxidative stress|
|germ cell development|
|regulation of animal organ morphogenesis|
|synapse organization|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of neuron differentiation|
|response to oxidative stress|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|synaptic signaling|
|positive regulation of neurogenesis|
|protein localization to membrane|
|cell division|
|positive regulation of nervous system development|
|positive regulation of cell development|
|spermatogenesis|
|male gamete generation|
|behavior|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|gamete generation|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|membrane organization|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|multi-organism reproductive process|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|DNA binding|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.26|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.94|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13296
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ETV5 Expression in NALM6 Cells: 3.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>