EXD1 [The Human Chemical-Genetic Interaction Map Project]

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======= EXD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EXD1
  * **<color #00a2e8>Official Name</color>**: exonuclease 3'-5' domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=161829|161829]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NHP7|Q8NHP7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EXD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EXD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing- triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity). {ECO:0000250|UniProtKB:H9IUR0, ECO:0000250|UniProtKB:Q8CDF7}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DNA pol A exo1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PET complex|
|P granule|
|piRNA metabolic process|
|3-5 exonuclease activity|
|gene silencing by RNA|
|gene silencing|
|meiotic cell cycle|
|nucleic acid phosphodiester bond hydrolysis|
|ncRNA metabolic process|
|protein homodimerization activity|
|cell cycle|
|RNA binding|
|reproductive process|
|reproduction|
|RNA metabolic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.74|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.517|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.498|
|[[:human genes:t:tceb3c|TCEB3C]]|0.497|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.491|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.49|
|[[:human genes:t:tfip11|TFIP11]]|0.474|
|[[:human genes:m:mylk3|MYLK3]]|0.468|
|[[:human genes:o:orc6|ORC6]]|0.461|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.456|
|[[:human genes:h:hivep3|HIVEP3]]|0.454|
|[[:human genes:o:orc1|ORC1]]|0.453|
|[[:human genes:t:ticrr|TICRR]]|0.447|
|[[:human genes:s:slc4a1|SLC4A1]]|0.446|
|[[:human genes:r:rpl26|RPL26]]|0.446|
|[[:human genes:p:polr2j3|POLR2J3]]|0.446|
|[[:human genes:s:sf3a3|SF3A3]]|0.443|
|[[:human genes:c:chaf1a|CHAF1A]]|0.443|
|[[:human genes:c:ccna2|CCNA2]]|0.443|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.442|
|[[:human genes:p:prim1|PRIM1]]|0.441|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.441|
|[[:human genes:n:narfl|NARFL]]|0.44|
|[[:human genes:c:cgb2|CGB2]]|0.439|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.436|
|[[:human genes:n:nup54|NUP54]]|0.435|
|[[:human genes:s:snip1|SNIP1]]|0.434|
|[[:human genes:c:c14orf93|C14orf93]]|0.433|
|[[:human genes:m:mt1e|MT1E]]|0.433|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.432|
|[[:human genes:e:exosc5|EXOSC5]]|0.43|
|[[:human genes:r:rps12|RPS12]]|0.428|
|[[:human genes:a:aamp|AAMP]]|0.427|
|[[:human genes:s:syt9|SYT9]]|0.426|
|[[:human genes:k:kctd17|KCTD17]]|0.426|
|[[:human genes:c:copg1|COPG1]]|0.424|
|[[:human genes:c:chd4|CHD4]]|0.423|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.42|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.415|
|[[:human genes:r:rnf113a|RNF113A]]|0.415|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.415|
|[[:human genes:s:snrnp70|SNRNP70]]|0.414|
|[[:human genes:r:rps2|RPS2]]|0.414|
|[[:human genes:c:cdca3|CDCA3]]|0.412|
|[[:human genes:s:supt6h|SUPT6H]]|0.412|
|[[:human genes:w:wdr87|WDR87]]|0.412|
|[[:human genes:c:cactin|CACTIN]]|0.411|
|[[:human genes:c:c2orf27a|C2orf27A]]|0.411|
|[[:human genes:v:vasn|VASN]]|0.41|
|[[:human genes:u:utp3|UTP3]]|0.409|
|[[:human genes:r:rpl37a|RPL37A]]|0.407|
|[[:human genes:c:cmya5|CMYA5]]|0.406|
|[[:human genes:i:ik|IK]]|0.406|
|[[:human genes:s:sec13|SEC13]]|0.406|
|[[:human genes:t:tsg101|TSG101]]|0.405|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.405|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.405|
|[[:human genes:n:nol10|NOL10]]|0.405|
|[[:human genes:t:tspy8|TSPY8]]|0.404|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.404|
|[[:human genes:a:aqr|AQR]]|0.404|
|[[:human genes:s:supt5h|SUPT5H]]|0.403|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.403|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.403|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.403|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.402|
|[[:human genes:c:cope|COPE]]|0.401|
|[[:human genes:n:nupl1|NUPL1]]|0.4|
|[[:human genes:p:pcf11|PCF11]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2075
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EXD1 Expression in NALM6 Cells: 1.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>