EXOC1 [The Human Chemical-Genetic Interaction Map Project]

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======= EXOC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EXOC1
  * **<color #00a2e8>Official Name</color>**: exocyst complex component 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55763|55763]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NV70|Q9NV70]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EXOC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EXOC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607879|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic side of apical plasma membrane|
|exocyst localization|
|exocyst|
|GTP-Rho binding|
|cellular protein-containing complex localization|
|Flemming body|
|Golgi to plasma membrane transport|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|phosphatidylinositol-4,5-bisphosphate binding|
|vesicle-mediated transport to the plasma membrane|
|post-Golgi vesicle-mediated transport|
|regulation of macroautophagy|
|defense response to virus|
|protein-containing complex localization|
|positive regulation of protein secretion|
|response to virus|
|positive regulation of peptide secretion|
|regulation of autophagy|
|Golgi vesicle transport|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|perinuclear region of cytoplasm|
|viral process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|symbiotic process|
|exocytosis|
|regulation of secretion|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|defense response to other organism|
|positive regulation of transport|
|regulation of catabolic process|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|immune effector process|
|secretion|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|protein transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.76|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.545|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2016
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EXOC1 Expression in NALM6 Cells: 5.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>