EXOG [The Human Chemical-Genetic Interaction Map Project]

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======= EXOG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EXOG
  * **<color #00a2e8>Official Name</color>**: exo/endonuclease G
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9941|9941]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2C4|Q9Y2C4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EXOG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EXOG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604051|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity. {ECO:0000269|PubMed:18187503}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Endonuclease NS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|exodeoxyribonuclease activity|
|single-stranded DNA endodeoxyribonuclease activity|
|5-3 exonuclease activity|
|apoptotic DNA fragmentation|
|DNA catabolic process, endonucleolytic|
|apoptotic nuclear changes|
|cellular component disassembly involved in execution phase of apoptosis|
|endoribonuclease activity|
|DNA catabolic process|
|endonuclease activity|
|execution phase of apoptosis|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|RNA phosphodiester bond hydrolysis|
|nucleic acid binding|
|nucleic acid phosphodiester bond hydrolysis|
|nucleobase-containing compound catabolic process|
|mitochondrial inner membrane|
|cellular component disassembly|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|protein-containing complex|
|DNA metabolic process|
|cellular macromolecule catabolic process|
|apoptotic process|
|macromolecule catabolic process|
|programmed cell death|
|cell death|
|mitochondrion|
|RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.29|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.14|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.05|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.85|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.72|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.72|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.73|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9464
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EXOG Expression in NALM6 Cells: 5.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>