EXTL1 [The Human Chemical-Genetic Interaction Map Project]

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======= EXTL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EXTL1
  * **<color #00a2e8>Official Name</color>**: exostosin like glycosyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2134|2134]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92935|Q92935]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EXTL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EXTL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601738|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable glycosyltransferase. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco transf 64|
|Exostosin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|
|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|
|transferase activity, transferring glycosyl groups|
|acetylglucosaminyltransferase activity|
|glucuronosyltransferase activity|
|heparan sulfate proteoglycan biosynthetic process|
|heparan sulfate proteoglycan metabolic process|
|polysaccharide biosynthetic process|
|cellular polysaccharide biosynthetic process|
|IRE1-mediated unfolded protein response|
|cellular carbohydrate biosynthetic process|
|proteoglycan biosynthetic process|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|proteoglycan metabolic process|
|glycosaminoglycan biosynthetic process|
|endoplasmic reticulum unfolded protein response|
|aminoglycan biosynthetic process|
|cellular response to unfolded protein|
|carbohydrate biosynthetic process|
|cellular response to topologically incorrect protein|
|glycosaminoglycan metabolic process|
|response to unfolded protein|
|aminoglycan metabolic process|
|cellular carbohydrate metabolic process|
|response to topologically incorrect protein|
|macromolecule glycosylation|
|protein glycosylation|
|response to endoplasmic reticulum stress|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate metabolic process|
|skeletal system development|
|carbohydrate derivative biosynthetic process|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-2.69|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2.3|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.27|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.89|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.81|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.77|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.75|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.85|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2696
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EXTL1 Expression in NALM6 Cells: -2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>