F12 [The Human Chemical-Genetic Interaction Map Project]

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======= F12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: F12
  * **<color #00a2e8>Official Name</color>**: coagulation factor XII
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2161|2161]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00748|P00748]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=F12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20F12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610619|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. {ECO:0000269|PubMed:21304106}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn1|
|Kringle|
|Trypsin|
|fn2|
|EGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Factor XII activation|
|plasma kallikrein-kinin cascade|
|kinin cascade|
|positive regulation of fibrinolysis|
|positive regulation of plasminogen activation|
|regulation of plasminogen activation|
|regulation of fibrinolysis|
|protein autoprocessing|
|blood coagulation, intrinsic pathway|
|fibrinolysis|
|positive regulation of protein processing|
|positive regulation of protein maturation|
|positive regulation of blood coagulation|
|misfolded protein binding|
|positive regulation of hemostasis|
|response to misfolded protein|
|blood coagulation, fibrin clot formation|
|protein activation cascade|
|positive regulation of coagulation|
|positive regulation of acute inflammatory response|
|zymogen activation|
|regulation of acute inflammatory response|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|positive regulation of wound healing|
|rough endoplasmic reticulum|
|positive regulation of response to wounding|
|regulation of protein processing|
|regulation of protein maturation|
|acute inflammatory response|
|negative regulation of wound healing|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|regulation of wound healing|
|positive regulation of inflammatory response|
|protein processing|
|serine-type endopeptidase activity|
|regulation of response to wounding|
|response to topologically incorrect protein|
|protein maturation|
|blood coagulation|
|coagulation|
|hemostasis|
|regulation of inflammatory response|
|positive regulation of proteolysis|
|negative regulation of response to external stimulus|
|collagen-containing extracellular matrix|
|positive regulation of defense response|
|wound healing|
|regulation of body fluid levels|
|inflammatory response|
|response to wounding|
|positive regulation of response to external stimulus|
|calcium ion binding|
|regulation of proteolysis|
|regulation of defense response|
|innate immune response|
|defense response to other organism|
|regulation of response to external stimulus|
|negative regulation of multicellular organismal process|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|immune response|
|extracellular region|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-1.9|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.83|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.79|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.81|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.96|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.96|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.97|
|[[:results:exp495|IWR1 50μM R08 exp495]]|2.04|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12239
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='F12 Expression in NALM6 Cells: 1.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>