FAM175B [The Human Chemical-Genetic Interaction Map Project]

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======= FAM175B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ABRAXAS2
  * **<color #00a2e8>Official Name</color>**: abraxas 2, BRISC complex subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23172|23172]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15018|Q15018]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM175B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM175B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611144|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys- 63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148). {ECO:0000250|UniProtKB:Q3TCJ1, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20032457, ECO:0000269|PubMed:20656690, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:25283148}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|BRISC complex|
|microtubule minus-end|
|spindle pole centrosome|
|attachment of spindle microtubules to kinetochore|
|polyubiquitin modification-dependent protein binding|
|protein K63-linked deubiquitination|
|mitotic spindle assembly|
|response to ischemia|
|mitotic spindle organization|
|spindle assembly|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic nuclear division|
|spindle organization|
|midbody|
|nuclear chromosome segregation|
|microtubule binding|
|chromosome segregation|
|protein deubiquitination|
|nuclear division|
|protein modification by small protein removal|
|organelle fission|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|organelle assembly|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|cytoskeleton organization|
|proteolysis|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-3.02|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.29|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.71|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.75|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|1.82|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.96|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17944
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM175B Expression in NALM6 Cells: 5.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>