FAM208A [The Human Chemical-Genetic Interaction Map Project]

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======= FAM208A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TASOR
  * **<color #00a2e8>Official Name</color>**: transcription activation suppressor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23272|23272]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UK61|Q9UK61]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM208A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM208A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616493|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. {ECO:0000269|PubMed:26022416}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3715|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to heterochromatin|
|positive regulation of methylation-dependent chromatin silencing|
|regulation of methylation-dependent chromatin silencing|
|positive regulation of chromatin silencing|
|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|
|regulation of single stranded viral RNA replication via double stranded DNA intermediate|
|protein localization to chromatin|
|heterochromatin|
|regulation of chromatin silencing|
|negative regulation of viral genome replication|
|protein localization to chromosome|
|negative regulation of viral life cycle|
|negative regulation of gene expression, epigenetic|
|regulation of viral genome replication|
|negative regulation of viral process|
|positive regulation of chromatin organization|
|regulation of gene silencing|
|regulation of viral life cycle|
|positive regulation of chromosome organization|
|regulation of chromatin organization|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of gene expression, epigenetic|
|regulation of chromosome organization|
|chromatin binding|
|positive regulation of organelle organization|
|protein localization to organelle|
|regulation of multi-organism process|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|RNA binding|
|cellular protein localization|
|cellular macromolecule localization|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.9|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.21|
|[[:results:exp539|42°C R08 exp539]]|-1.88|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.71|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.77|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.82|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:morc2|MORC2]]|0.49|
|[[:human genes:m:mphosph8|MPHOSPH8]]|0.48|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2876
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM208A Expression in NALM6 Cells: 7.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>