FAM3A [The Human Chemical-Genetic Interaction Map Project]

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======= FAM3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAM3A
  * **<color #00a2e8>Official Name</color>**: FAM3 metabolism regulating signaling molecule A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60343|60343]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P98173|P98173]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300492|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cytokine-like protein. The expression of this gene may be regulated by peroxisome proliferator-activated receptor gamma, and the encoded protein may be involved in the regulation of glucose and lipid metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a defensin against invading fungal microorganisms.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of antifungal innate immune response|
|regulation of antifungal innate immune response|
|regulation of defense response to fungus|
|antifungal humoral response|
|negative regulation of gluconeogenesis|
|defense response to fungus|
|negative regulation of cellular carbohydrate metabolic process|
|regulation of gluconeogenesis|
|negative regulation of carbohydrate metabolic process|
|response to fungus|
|negative regulation of innate immune response|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|negative regulation of small molecule metabolic process|
|negative regulation of response to biotic stimulus|
|regulation of carbohydrate biosynthetic process|
|antimicrobial humoral response|
|regulation of glucose metabolic process|
|regulation of cellular carbohydrate metabolic process|
|negative regulation of immune response|
|regulation of lipid biosynthetic process|
|regulation of carbohydrate metabolic process|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|humoral immune response|
|negative regulation of response to external stimulus|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|negative regulation of immune system process|
|cellular component|
|regulation of innate immune response|
|regulation of response to biotic stimulus|
|molecular function|
|regulation of defense response|
|regulation of multi-organism process|
|defense response to other organism|
|regulation of response to external stimulus|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of response to stimulus|
|regulation of immune system process|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-3.3|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17705
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM3A Expression in NALM6 Cells: 4.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>