FAM50A [The Human Chemical-Genetic Interaction Map Project]

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======= FAM50A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAM50A
  * **<color #00a2e8>Official Name</color>**: family with sequence similarity 50 member A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9130|9130]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14320|Q14320]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM50A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM50A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300453|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the FAM50 family. The encoded protein is highly conserved in length and sequence across different species. It is a basic protein containing a nuclear localization signal, and may function as a DNA-binding protein or a transcriptional factor. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be a DNA-binding protein or transcriptional factor. {ECO:0000269|PubMed:9339379}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|XAP5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spermatogenesis|
|male gamete generation|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|RNA binding|
|reproductive process|
|reproduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-2.39|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-2.08|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.96|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.73|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.74|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.91|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.91|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.91|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.95|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.17|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.21|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.22|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 223/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|7/28|
|blood|15/26|
|bone|3/26|
|breast|7/30|
|central nervous system|22/49|
|cervix|1/4|
|colorectal|10/17|
|esophagus|4/11|
|fibroblast|1/1|
|gastric|7/14|
|kidney|3/18|
|liver|6/19|
|lung|16/72|
|lymphocyte|9/16|
|ovary|6/25|
|pancreas|5/22|
|peripheral nervous system|5/15|
|plasma cell|4/12|
|prostate|0/1|
|skin|7/20|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|13/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 99
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM50A Expression in NALM6 Cells: 5.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>