FAM65B [The Human Chemical-Genetic Interaction Map Project]

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======= FAM65B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RIPOR2
  * **<color #00a2e8>Official Name</color>**: RHO family interacting cell polarization regulator 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9750|9750]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4F9|Q9Y4F9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM65B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM65B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611410|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an atypical inhibitor of the small G protein RhoA. Inhibition of RhoA activity by the encoded protein mediates myoblast fusion and polarization of T cells and neutrophils. The encoded protein is a component of hair cell stereocilia that is essential for hearing. A splice site mutation in this gene results in hearing loss in human patients. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:24687993, PubMed:23241886, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875). {ECO:0000250|UniProtKB:Q80U16, ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:23241886, ECO:0000269|PubMed:24687993, ECO:0000269|PubMed:24958875, ECO:0000269|PubMed:27556504}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of Rho guanyl-nucleotide exchange factor activity|
|negative regulation of establishment of T cell polarity|
|regulation of protein localization to cell leading edge|
|negative regulation of Ras GTPase binding|
|negative regulation of protein localization to cell leading edge|
|regulation of Ras GTPase binding|
|regulation of Rho guanyl-nucleotide exchange factor activity|
|regulation of establishment of T cell polarity|
|negative regulation of guanyl-nucleotide exchange factor activity|
|stereocilium membrane|
|negative regulation of T cell migration|
|regulation of guanyl-nucleotide exchange factor activity|
|positive regulation of neutrophil extravasation|
|regulation of neutrophil extravasation|
|auditory receptor cell stereocilium organization|
|regulation of GTP binding|
|auditory receptor cell morphogenesis|
|negative regulation of lymphocyte migration|
|positive regulation of cellular extravasation|
|auditory receptor cell development|
|positive regulation of myoblast fusion|
|regulation of myoblast fusion|
|regulation of establishment of cell polarity|
|positive regulation of myoblast differentiation|
|negative regulation of Rho protein signal transduction|
|positive regulation of neutrophil chemotaxis|
|regulation of establishment or maintenance of cell polarity|
|skeletal muscle fiber development|
|positive regulation of granulocyte chemotaxis|
|inner ear auditory receptor cell differentiation|
|positive regulation of syncytium formation by plasma membrane fusion|
|myotube cell development|
|inner ear receptor cell stereocilium organization|
|positive regulation of neutrophil migration|
|14-3-3 protein binding|
|regulation of cellular extravasation|
|regulation of syncytium formation by plasma membrane fusion|
|regulation of neutrophil chemotaxis|
|positive regulation of filopodium assembly|
|positive regulation of myotube differentiation|
|stereocilium|
|hair cell differentiation|
|regulation of neutrophil migration|
|inner ear receptor cell development|
|regulation of granulocyte chemotaxis|
|regulation of T cell migration|
|neuroepithelial cell differentiation|
|regulation of filopodium assembly|
|negative regulation of leukocyte migration|
|columnar/cuboidal epithelial cell development|
|negative regulation of Ras protein signal transduction|
|inner ear receptor cell differentiation|
|regulation of myoblast differentiation|
|regulation of myotube differentiation|
|mechanoreceptor differentiation|
|myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|muscle fiber development|
|negative regulation of small GTPase mediated signal transduction|
|regulation of lymphocyte migration|
|filopodium|
|cellular response to mechanical stimulus|
|positive regulation of muscle cell differentiation|
|positive regulation of leukocyte chemotaxis|
|cellular response to chemokine|
|response to chemokine|
|columnar/cuboidal epithelial cell differentiation|
|inner ear morphogenesis|
|positive regulation of plasma membrane bounded cell projection assembly|
|regulation of striated muscle cell differentiation|
|negative regulation of protein binding|
|negative regulation of T cell activation|
|regulation of leukocyte chemotaxis|
|negative regulation of cellular protein localization|
|ear morphogenesis|
|negative regulation of leukocyte cell-cell adhesion|
|skeletal muscle tissue development|
|positive regulation of leukocyte migration|
|skeletal muscle organ development|
|striated muscle cell development|
|positive regulation of chemotaxis|
|regulation of Rho protein signal transduction|
|negative regulation of lymphocyte activation|
|sensory perception of sound|
|muscle cell development|
|regulation of muscle cell differentiation|
|sensory perception of mechanical stimulus|
|negative regulation of binding|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|positive regulation of binding|
|epithelial cell development|
|inner ear development|
|regulation of leukocyte migration|
|negative regulation of cell activation|
|regulation of plasma membrane bounded cell projection assembly|
|striated muscle cell differentiation|
|regulation of cell projection assembly|
|regulation of chemotaxis|
|response to mechanical stimulus|
|regulation of protein binding|
|ear development|
|regulation of Ras protein signal transduction|
|muscle cell differentiation|
|sensory organ morphogenesis|
|negative regulation of cell migration|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|muscle organ development|
|regulation of leukocyte cell-cell adhesion|
|muscle tissue development|
|negative regulation of cellular component movement|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|epidermal cell differentiation|
|regulation of T cell activation|
|apical plasma membrane|
|negative regulation of locomotion|
|cellular response to external stimulus|
|protein homooligomerization|
|regulation of small GTPase mediated signal transduction|
|cytoskeleton|
|regulation of binding|
|positive regulation of cell projection organization|
|regulation of cell-cell adhesion|
|epidermis development|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|negative regulation of immune system process|
|muscle structure development|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|regulation of lymphocyte activation|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|sensory organ development|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|embryonic morphogenesis|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|regulation of cell activation|
|neuron projection development|
|regulation of cell adhesion|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|sensory perception|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|neuron differentiation|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|regulation of response to external stimulus|
|response to cytokine|
|epithelium development|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cell projection organization|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|generation of neurons|
|protein-containing complex assembly|
|establishment of protein localization|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of immune system process|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14018
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM65B Expression in NALM6 Cells: 3.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>