FAM86A [The Human Chemical-Genetic Interaction Map Project]

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======= FAM86A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EEF2KMT
  * **<color #00a2e8>Official Name</color>**: eukaryotic elongation factor 2 lysine methyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=196483|196483]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96G04|Q96G04]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM86A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM86A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615263|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'. {ECO:0000269|PubMed:25231979}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 16|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein-lysine N-methyltransferase activity|
|peptidyl-lysine trimethylation|
|peptidyl-lysine methylation|
|protein alkylation|
|protein methylation|
|macromolecule methylation|
|methylation|
|peptidyl-lysine modification|
|protein-containing complex|
|peptidyl-amino acid modification|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 176/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|12/28|
|bone|7/26|
|breast|10/33|
|central nervous system|4/56|
|cervix|3/4|
|colorectal|2/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|8/21|
|liver|6/20|
|lung|17/75|
|lymphocyte|5/16|
|ovary|5/26|
|pancreas|7/24|
|peripheral nervous system|4/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|8/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7294
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM86A Expression in NALM6 Cells: 4.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>