FAM86B2 [The Human Chemical-Genetic Interaction Map Project]

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======= FAM86B2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAM86B2
  * **<color #00a2e8>Official Name</color>**: family with sequence similarity 86 member B2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=653333|653333]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0C5J1|P0C5J1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM86B2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM86B2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616123|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Methyltransf 16|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|methyltransferase activity|
|methylation|
|protein-containing complex|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.522|
|[[:human genes:v:vasn|VASN]]|0.485|
|[[:human genes:o:ogfr|OGFR]]|0.461|
|[[:human genes:r:rps2|RPS2]]|0.459|
|[[:human genes:t:twistnb|TWISTNB]]|0.457|
|[[:human genes:p:pola1|POLA1]]|0.453|
|[[:human genes:z:zfand5|ZFAND5]]|0.448|
|[[:human genes:r:rrm1|RRM1]]|0.44|
|[[:human genes:n:ncapg|NCAPG]]|0.438|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.437|
|[[:human genes:c:cdc73|CDC73]]|0.437|
|[[:human genes:o:or10g3|OR10G3]]|0.437|
|[[:human genes:c:c14orf93|C14orf93]]|0.437|
|[[:human genes:p:psmb4|PSMB4]]|0.436|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.435|
|[[:human genes:r:rps20|RPS20]]|0.428|
|[[:human genes:p:psma6|PSMA6]]|0.427|
|[[:human genes:p:pwp2|PWP2]]|0.425|
|[[:human genes:c:chd4|CHD4]]|0.424|
|[[:human genes:r:rpl35|RPL35]]|0.424|
|[[:human genes:m:mms22l|MMS22L]]|0.422|
|[[:human genes:h:hap1|HAP1]]|0.421|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.421|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.421|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.421|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.421|
|[[:human genes:e:elmod3|ELMOD3]]|0.421|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.42|
|[[:human genes:n:nup160|NUP160]]|0.419|
|[[:human genes:s:ssh2|SSH2]]|0.418|
|[[:human genes:c:ccna2|CCNA2]]|0.416|
|[[:human genes:s:stil|STIL]]|0.416|
|[[:human genes:p:palb2|PALB2]]|0.415|
|[[:human genes:f:fam160a1|FAM160A1]]|0.414|
|[[:human genes:p:psmd2|PSMD2]]|0.413|
|[[:human genes:r:rpsa|RPSA]]|0.41|
|[[:human genes:z:znf106|ZNF106]]|0.409|
|[[:human genes:t:tceb3c|TCEB3C]]|0.409|
|[[:human genes:e:exosc9|EXOSC9]]|0.409|
|[[:human genes:s:s1pr4|S1PR4]]|0.409|
|[[:human genes:p:polr2j3|POLR2J3]]|0.408|
|[[:human genes:p:psma7|PSMA7]]|0.407|
|[[:human genes:r:rad51|RAD51]]|0.407|
|[[:human genes:n:nop16|NOP16]]|0.407|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.405|
|[[:human genes:p:psap|PSAP]]|0.405|
|[[:human genes:r:rnf121|RNF121]]|0.405|
|[[:human genes:s:slc38a7|SLC38A7]]|0.404|
|[[:human genes:k:kpnb1|KPNB1]]|0.402|
|[[:human genes:g:gga3|GGA3]]|0.402|
|[[:human genes:a:atxn1|ATXN1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2230
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM86B2 Expression in NALM6 Cells: -0.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>