FAM98B [The Human Chemical-Genetic Interaction Map Project]

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======= FAM98B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAM98B
  * **<color #00a2e8>Official Name</color>**: family with sequence similarity 98 member B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=283742|283742]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q52LJ0|Q52LJ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM98B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM98B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616142|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436). Promotes colorectal cancer cell malignancy (PubMed:28040436). {ECO:0000269|PubMed:28040436}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2465|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA-splicing ligase complex|
|protein methyltransferase activity|
|tRNA splicing, via endonucleolytic cleavage and ligation|
|RNA splicing, via endonucleolytic cleavage and ligation|
|tRNA processing|
|protein methylation|
|protein alkylation|
|tRNA metabolic process|
|macromolecule methylation|
|methylation|
|ncRNA processing|
|RNA splicing|
|ncRNA metabolic process|
|intracellular membrane-bounded organelle|
|RNA processing|
|positive regulation of cell population proliferation|
|identical protein binding|
|RNA binding|
|regulation of cell population proliferation|
|RNA metabolic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.96|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.94|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.7|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.7|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.73|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.74|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.76|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.76|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.78|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.8|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.81|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.83|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.83|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.85|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.87|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.91|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.06|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.11|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.13|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.14|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.17|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.22|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|2.22|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.26|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|2.27|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.28|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2.29|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.3|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.41|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.44|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.57|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.67|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|3.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:elp2|ELP2]]|0.528|
|[[:human genes:k:kti12|KTI12]]|0.52|
|[[:human genes:e:elp6|ELP6]]|0.516|
|[[:human genes:u:urm1|URM1]]|0.447|
|[[:human genes:c:ctu1|CTU1]]|0.443|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.439|
|[[:human genes:d:ddx1|DDX1]]|0.427|
|[[:human genes:n:nr2c2ap|NR2C2AP]]|0.425|
|[[:human genes:m:mocs3|MOCS3]]|0.41|
|[[:human genes:e:elp5|ELP5]]|0.41|
|[[:human genes:e:elp3|ELP3]]|0.409|
|[[:human genes:f:fkbpl|FKBPL]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 22/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|6/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2187
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM98B Expression in NALM6 Cells: 5.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>