FARSA [The Human Chemical-Genetic Interaction Map Project]

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======= FARSA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FARSA
  * **<color #00a2e8>Official Name</color>**: phenylalanyl-tRNA synthetase subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2193|2193]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y285|Q9Y285]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FARSA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FARSA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602918|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA-synt 2d|
|tRNA-synt 2b|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phenylalanine-tRNA ligase complex|
|phenylalanyl-tRNA aminoacylation|
|phenylalanine-tRNA ligase activity|
|protein heterotetramerization|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA binding|
|protein heterooligomerization|
|protein tetramerization|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|protein complex oligomerization|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|ATP binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp73|LJH685 5μM R02 exp73]]|-2.03|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.79|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.74|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.79|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.83|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.84|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2.01|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|2.17|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.35|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|2.53|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 154/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|4/28|
|bone|5/26|
|breast|10/33|
|central nervous system|9/56|
|cervix|1/4|
|colorectal|4/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|10/21|
|liver|5/20|
|lung|6/75|
|lymphocyte|4/16|
|ovary|3/26|
|pancreas|5/24|
|peripheral nervous system|4/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|10/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 220
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FARSA Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>