FAS [The Human Chemical-Genetic Interaction Map Project]

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======= FAS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAS
  * **<color #00a2e8>Official Name</color>**: Fas cell surface death receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=355|355]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25445|P25445]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/134637|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Death|
|TNFR c6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Fas signaling pathway|
|necroptotic signaling pathway|
|CD95 death-inducing signaling complex|
|cellular response to hyperoxia|
|death-inducing signaling complex|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|cellular response to increased oxygen levels|
|regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|response to hyperoxia|
|necroptotic process|
|programmed necrotic cell death|
|response to increased oxygen levels|
|necrotic cell death|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|cellular response to amino acid starvation|
|response to amino acid starvation|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|cellular response to mechanical stimulus|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|kinase binding|
|extrinsic apoptotic signaling pathway|
|negative regulation of extrinsic apoptotic signaling pathway|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|transmembrane signaling receptor activity|
|positive regulation of cysteine-type endopeptidase activity|
|cellular response to starvation|
|regulation of extrinsic apoptotic signaling pathway|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|positive regulation of peptidase activity|
|response to starvation|
|calmodulin binding|
|signaling receptor activity|
|response to mechanical stimulus|
|cellular response to oxygen levels|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of apoptotic signaling pathway|
|membrane raft|
|regulation of stress-activated MAPK cascade|
|cellular response to nutrient levels|
|regulation of stress-activated protein kinase signaling cascade|
|regulation of cysteine-type endopeptidase activity|
|cellular response to extracellular stimulus|
|nuclear body|
|apoptotic signaling pathway|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|cellular response to external stimulus|
|positive regulation of proteolysis|
|response to oxygen levels|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|response to nutrient levels|
|response to extracellular stimulus|
|cell surface|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|programmed cell death|
|positive regulation of phosphorylation|
|identical protein binding|
|cell death|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.98|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.81|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.71|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.72|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11135
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAS Expression in NALM6 Cells: 2.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>