FASN [The Human Chemical-Genetic Interaction Map Project]

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======= FASN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FASN
  * **<color #00a2e8>Official Name</color>**: fatty acid synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2194|2194]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49327|P49327]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FASN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FASN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600212|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acyl transf 1|
|ketoacyl-synt|
|KR|
|PP-binding|
|Methyltransf 12|
|adh short|
|Ketoacyl-synt C|
|ADH zinc N|
|Thioesterase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphopantetheine binding|
|3-oxo-pimeloyl-[acp] methyl ester reductase activity|
|enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity|
|3-oxo-glutaryl-[acp] methyl ester reductase activity|
|(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity|
|3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity|
|[acyl-carrier-protein] S-acetyltransferase activity|
|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|
|3-oxoacyl-[acyl-carrier-protein] synthase activity|
|oleoyl-[acyl-carrier-protein] hydrolase activity|
|myristoyl-[acyl-carrier-protein] hydrolase activity|
|[acyl-carrier-protein] S-malonyltransferase activity|
|palmitoyl-[acyl-carrier-protein] hydrolase activity|
|ether biosynthetic process|
|glycerol ether biosynthetic process|
|ether lipid biosynthetic process|
|neutrophil differentiation|
|glycogen granule|
|cellular lipid biosynthetic process|
|ether lipid metabolic process|
|glycerol ether metabolic process|
|establishment of endothelial intestinal barrier|
|NADPH binding|
|ether metabolic process|
|mononuclear cell differentiation|
|monocyte differentiation|
|granulocyte differentiation|
|cellular response to interleukin-4|
|acetyl-CoA metabolic process|
|response to interleukin-4|
|establishment of endothelial barrier|
|fatty-acyl-CoA biosynthetic process|
|fatty-acyl-CoA metabolic process|
|regulation of sterol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|acyl-CoA biosynthetic process|
|thioester biosynthetic process|
|endothelial cell development|
|regulation of cholesterol metabolic process|
|drug binding|
|purine nucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|ribonucleoside bisphosphate biosynthetic process|
|regulation of alcohol biosynthetic process|
|endothelial cell differentiation|
|regulation of steroid biosynthetic process|
|fatty acid derivative biosynthetic process|
|endothelium development|
|acyl-CoA metabolic process|
|thioester metabolic process|
|melanosome|
|myeloid leukocyte differentiation|
|regulation of steroid metabolic process|
|fatty acid biosynthetic process|
|osteoblast differentiation|
|mammary gland development|
|nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|coenzyme biosynthetic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|fatty acid derivative metabolic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|sulfur compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|regulation of lipid biosynthetic process|
|epithelial cell development|
|cofactor biosynthetic process|
|myeloid cell differentiation|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|ossification|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cadherin binding|
|purine ribonucleotide metabolic process|
|fatty acid metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|leukocyte differentiation|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|regulation of lipid metabolic process|
|gland development|
|regulation of small molecule metabolic process|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|amide biosynthetic process|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|hemopoiesis|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|hematopoietic or lymphoid organ development|
|carbohydrate derivative biosynthetic process|
|immune system development|
|epithelial cell differentiation|
|cellular amide metabolic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|Golgi apparatus|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cell development|
|small molecule metabolic process|
|tissue development|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 20/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2224
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FASN Expression in NALM6 Cells: 9.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>