FAT1 [The Human Chemical-Genetic Interaction Map Project]

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======= FAT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAT1
  * **<color #00a2e8>Official Name</color>**: FAT atypical cadherin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2195|2195]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14517|Q14517]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600976|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Laminin G 1|
|Cadherin|
|EGF CA|
|Laminin G 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|epithelial cell morphogenesis|
|establishment or maintenance of epithelial cell apical/basal polarity|
|establishment or maintenance of apical/basal cell polarity|
|establishment or maintenance of bipolar cell polarity|
|filopodium|
|camera-type eye morphogenesis|
|eye morphogenesis|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|cell-cell junction|
|lamellipodium|
|epithelial cell development|
|establishment or maintenance of cell polarity|
|actin filament organization|
|sensory organ morphogenesis|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|camera-type eye development|
|apical plasma membrane|
|eye development|
|visual system development|
|sensory system development|
|focal adhesion|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|cell-cell adhesion|
|sensory organ development|
|cell morphogenesis involved in differentiation|
|actin filament-based process|
|epithelial cell differentiation|
|perinuclear region of cytoplasm|
|calcium ion binding|
|cell morphogenesis|
|cellular component morphogenesis|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|locomotion|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|cell development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12065
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAT1 Expression in NALM6 Cells: 7.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>