FBXO18 [The Human Chemical-Genetic Interaction Map Project]

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======= FBXO18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBH1
  * **<color #00a2e8>Official Name</color>**: F-box DNA helicase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84893|84893]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NFZ0|Q8NFZ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBXO18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBXO18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607222|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  3'-5' DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316). Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013). Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361). In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578). {ECO:0000269|PubMed:11956208, ECO:0000269|PubMed:17724085, ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23319600, ECO:0000269|PubMed:23361013, ECO:0000269|PubMed:25585578, ECO:0000269|PubMed:25772361}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F-box-like|
|F-box|
|UvrD-helicase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to intra-S DNA damage checkpoint signaling|
|DNA translocase activity|
|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|response to DNA damage checkpoint signaling|
|response to cell cycle checkpoint signaling|
|response to DNA integrity checkpoint signaling|
|negative regulation of chromatin binding|
|replication fork protection|
|3-5 DNA helicase activity|
|negative regulation of double-strand break repair via homologous recombination|
|regulation of chromatin binding|
|DNA catabolic process, endonucleolytic|
|negative regulation of DNA-dependent DNA replication|
|DNA catabolic process|
|negative regulation of double-strand break repair|
|replication fork processing|
|negative regulation of DNA repair|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|DNA-dependent DNA replication maintenance of fidelity|
|negative regulation of DNA replication|
|negative regulation of DNA recombination|
|regulation of double-strand break repair via homologous recombination|
|regulation of DNA-dependent DNA replication|
|positive regulation of intrinsic apoptotic signaling pathway|
|DNA helicase activity|
|SCF ubiquitin ligase complex|
|regulation of double-strand break repair|
|negative regulation of response to DNA damage stimulus|
|double-strand break repair via homologous recombination|
|positive regulation of response to DNA damage stimulus|
|recombinational repair|
|double-stranded DNA binding|
|regulation of DNA recombination|
|single-stranded DNA binding|
|regulation of DNA replication|
|DNA duplex unwinding|
|chromatin|
|DNA geometric change|
|DNA-dependent DNA replication|
|negative regulation of DNA metabolic process|
|regulation of DNA repair|
|regulation of intrinsic apoptotic signaling pathway|
|negative regulation of binding|
|positive regulation of apoptotic signaling pathway|
|double-strand break repair|
|DNA replication|
|cellular response to biotic stimulus|
|regulation of response to DNA damage stimulus|
|DNA recombination|
|DNA conformation change|
|nucleic acid phosphodiester bond hydrolysis|
|regulation of DNA metabolic process|
|nucleobase-containing compound catabolic process|
|regulation of binding|
|regulation of apoptotic signaling pathway|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|DNA repair|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|protein ubiquitination|
|positive regulation of cell death|
|regulation of cellular response to stress|
|DNA metabolic process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|chromosome organization|
|cell death|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|response to biotic stimulus|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7654
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBXO18 Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>