FBXO31 [The Human Chemical-Genetic Interaction Map Project]

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======= FBXO31 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBXO31
  * **<color #00a2e8>Official Name</color>**: F-box protein 31
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79791|79791]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5XUX0|Q5XUX0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBXO31&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBXO31|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609102|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. {ECO:0000269|PubMed:16357137, ECO:0000269|PubMed:19412162}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F-box-like|
|F-box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of neuron migration|
|cyclin binding|
|positive regulation of dendrite morphogenesis|
|regulation of neuron migration|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|G1 DNA damage checkpoint|
|SCF ubiquitin ligase complex|
|positive regulation of dendrite development|
|anaphase-promoting complex-dependent catabolic process|
|regulation of dendrite morphogenesis|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|mitotic DNA damage checkpoint|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|negative regulation of cell cycle G1/S phase transition|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|regulation of dendrite development|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|positive regulation of cell morphogenesis involved in differentiation|
|regulation of cell cycle G1/S phase transition|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of cell cycle phase transition|
|positive regulation of neuron projection development|
|protein polyubiquitination|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of mitotic cell cycle|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|negative regulation of cell cycle process|
|proteasomal protein catabolic process|
|post-translational protein modification|
|positive regulation of neuron differentiation|
|neuronal cell body|
|positive regulation of cell projection organization|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|centrosome|
|regulation of neuron projection development|
|positive regulation of cell migration|
|positive regulation of cell motility|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|modification-dependent macromolecule catabolic process|
|positive regulation of locomotion|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|mitotic cell cycle|
|protein catabolic process|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|regulation of neurogenesis|
|regulation of cell migration|
|cellular macromolecule catabolic process|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of cellular component movement|
|cell cycle process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|proteolysis|
|cell cycle|
|positive regulation of developmental process|
|generation of neurons|
|neurogenesis|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4935
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBXO31 Expression in NALM6 Cells: 5.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>