FBXO32 [The Human Chemical-Genetic Interaction Map Project]

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======= FBXO32 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBXO32
  * **<color #00a2e8>Official Name</color>**: F-box protein 32
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114907|114907]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969P5|Q969P5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBXO32&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBXO32|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606604|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. {ECO:0000269|PubMed:15531760}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to denervation involved in regulation of muscle adaptation|
|response to muscle inactivity involved in regulation of muscle adaptation|
|response to muscle inactivity|
|response to inactivity|
|response to stimulus involved in regulation of muscle adaptation|
|cellular response to dexamethasone stimulus|
|response to dexamethasone|
|cellular response to glucocorticoid stimulus|
|cellular response to corticosteroid stimulus|
|SCF ubiquitin ligase complex|
|regulation of muscle adaptation|
|cellular response to ketone|
|response to antineoplastic agent|
|Z disc|
|response to glucocorticoid|
|response to corticosteroid|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|response to ketone|
|regulation of muscle system process|
|protein polyubiquitination|
|response to xenobiotic stimulus|
|response to steroid hormone|
|post-translational protein modification|
|cellular response to drug|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|regulation of system process|
|cellular response to hormone stimulus|
|protein ubiquitination|
|protein modification by small protein conjugation|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|protein modification by small protein conjugation or removal|
|response to drug|
|cellular response to oxygen-containing compound|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|response to oxygen-containing compound|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.75|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12912
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBXO32 Expression in NALM6 Cells: 0.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>