FBXO4 [The Human Chemical-Genetic Interaction Map Project]

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======= FBXO4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBXO4
  * **<color #00a2e8>Official Name</color>**: F-box protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26272|26272]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKT5|Q9UKT5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBXO4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBXO4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609090|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1. {ECO:0000269|PubMed:10531035, ECO:0000269|PubMed:16275645, ECO:0000269|PubMed:18598945, ECO:0000269|PubMed:20159592, ECO:0000269|PubMed:20181953}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F-box-like|
|F-box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|common myeloid progenitor cell proliferation|
|positive regulation of protein polyubiquitination|
|regulation of DNA damage checkpoint|
|regulation of protein polyubiquitination|
|negative regulation of fibroblast proliferation|
|negative regulation of protein localization to nucleus|
|regulation of cell cycle checkpoint|
|positive regulation of telomere maintenance via telomerase|
|positive regulation of telomere maintenance via telomere lengthening|
|protein destabilization|
|positive regulation of telomere maintenance|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|SCF ubiquitin ligase complex|
|positive regulation of DNA biosynthetic process|
|cellular response to ionizing radiation|
|regulation of fibroblast proliferation|
|regulation of telomere maintenance|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|ubiquitin ligase complex|
|negative regulation of cellular protein localization|
|regulation of DNA biosynthetic process|
|positive regulation of protein ubiquitination|
|regulation of protein localization to nucleus|
|positive regulation of protein modification by small protein conjugation or removal|
|response to ionizing radiation|
|positive regulation of chromosome organization|
|cellular response to radiation|
|positive regulation of DNA metabolic process|
|regulation of protein ubiquitination|
|regulation of response to DNA damage stimulus|
|ubiquitin protein ligase activity|
|regulation of protein modification by small protein conjugation or removal|
|ubiquitin-protein transferase activity|
|aging|
|regulation of protein stability|
|protein polyubiquitination|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|post-translational protein modification|
|response to radiation|
|posttranscriptional regulation of gene expression|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|cell population proliferation|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|negative regulation of cell population proliferation|
|protein catabolic process|
|protein ubiquitination|
|regulation of cellular response to stress|
|protein modification by small protein conjugation|
|protein homodimerization activity|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|proteolysis|
|regulation of organelle organization|
|regulation of response to stress|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11720
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBXO4 Expression in NALM6 Cells: 3.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>