FCER2 [The Human Chemical-Genetic Interaction Map Project]

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======= FCER2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FCER2
  * **<color #00a2e8>Official Name</color>**: Fc fragment of IgE receptor II
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2208|2208]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06734|P06734]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FCER2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FCER2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/151445|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of humoral immune response mediated by circulating immunoglobulin|
|IgE binding|
|regulation of humoral immune response mediated by circulating immunoglobulin|
|positive regulation of killing of cells of other organism|
|positive regulation of nitric-oxide synthase biosynthetic process|
|regulation of killing of cells of other organism|
|positive regulation of humoral immune response|
|regulation of nitric-oxide synthase biosynthetic process|
|positive regulation of nitric-oxide synthase activity|
|positive regulation of monooxygenase activity|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of B cell mediated immunity|
|regulation of nitric-oxide synthase activity|
|regulation of B cell mediated immunity|
|regulation of immunoglobulin mediated immune response|
|positive regulation of oxidoreductase activity|
|regulation of monooxygenase activity|
|positive regulation of cell killing|
|regulation of oxidoreductase activity|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of cell killing|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|Notch signaling pathway|
|integrin binding|
|positive regulation of leukocyte mediated immunity|
|regulation of humoral immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|regulation of adaptive immune response|
|carbohydrate binding|
|regulation of leukocyte mediated immunity|
|positive regulation of immune effector process|
|external side of plasma membrane|
|regulation of immune effector process|
|positive regulation of multi-organism process|
|cytokine-mediated signaling pathway|
|regulation of multi-organism process|
|positive regulation of immune response|
|cellular response to cytokine stimulus|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of immune system process|
|positive regulation of molecular function|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12768
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FCER2 Expression in NALM6 Cells: 1.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>