FCGRT [The Human Chemical-Genetic Interaction Map Project]

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======= FCGRT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FCGRT
  * **<color #00a2e8>Official Name</color>**: Fc fragment of IgG receptor and transporter
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2217|2217]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55899|P55899]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FCGRT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FCGRT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601437|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7964511, PubMed:10933786). Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus (PubMed:7964511). {ECO:0000250|UniProtKB:P13599, ECO:0000269|PubMed:10933786, ECO:0000269|PubMed:7964511}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MHC I|
|C1-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor|
|immunoglobulin transcytosis in epithelial cells|
|beta-2-microglobulin binding|
|IgG binding|
|transcytosis|
|peptide antigen binding|
|external side of plasma membrane|
|extracellular space|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.87|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.84|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.78|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.72|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.75|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.78|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.85|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.86|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.95|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|2.19|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9646
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FCGRT Expression in NALM6 Cells: 1.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>