FCN2 [The Human Chemical-Genetic Interaction Map Project]

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======= FCN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FCN2
  * **<color #00a2e8>Official Name</color>**: ficolin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2220|2220]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15485|Q15485]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FCN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FCN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601624|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. {ECO:0000269|PubMed:10679061, ECO:0000269|PubMed:17215869}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Collagen|
|Fibrinogen C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mannan binding|
|recognition of apoptotic cell|
|opsonization|
|complement activation, lectin pathway|
|proteoglycan binding|
|apoptotic cell clearance|
|collagen trimer|
|calcium-dependent protein binding|
|defense response to Gram-negative bacterium|
|defense response to Gram-positive bacterium|
|phagocytosis, recognition|
|blood microparticle|
|antigen binding|
|complement activation|
|cell recognition|
|phagocytosis|
|defense response to bacterium|
|humoral immune response|
|endocytosis|
|activation of immune response|
|import into cell|
|response to bacterium|
|innate immune response|
|positive regulation of immune response|
|defense response to other organism|
|immune effector process|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of immune system process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.99|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.13|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.54|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.538|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.524|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.511|
|[[:human genes:t:tceb3c|TCEB3C]]|0.503|
|[[:human genes:p:polr2j3|POLR2J3]]|0.498|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.494|
|[[:human genes:p:psma6|PSMA6]]|0.482|
|[[:human genes:k:kctd17|KCTD17]]|0.48|
|[[:human genes:d:ddtl|DDTL]]|0.478|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.473|
|[[:human genes:r:rad51|RAD51]]|0.471|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.47|
|[[:human genes:v:vasn|VASN]]|0.47|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.47|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.47|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.47|
|[[:human genes:i:ik|IK]]|0.465|
|[[:human genes:m:mt1e|MT1E]]|0.465|
|[[:human genes:c:cbwd3|CBWD3]]|0.465|
|[[:human genes:u:upf1|UPF1]]|0.461|
|[[:human genes:r:rps9|RPS9]]|0.453|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.451|
|[[:human genes:p:psmb2|PSMB2]]|0.449|
|[[:human genes:s:slc6a17|SLC6A17]]|0.444|
|[[:human genes:t:twistnb|TWISTNB]]|0.441|
|[[:human genes:p:psmb4|PSMB4]]|0.44|
|[[:human genes:n:npipb5|NPIPB5]]|0.439|
|[[:human genes:p:pan2|PAN2]]|0.438|
|[[:human genes:i:igfn1|IGFN1]]|0.437|
|[[:human genes:a:ankle2|ANKLE2]]|0.435|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.434|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.434|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.434|
|[[:human genes:c:cbwd5|CBWD5]]|0.432|
|[[:human genes:s:slc38a7|SLC38A7]]|0.431|
|[[:human genes:s:syt9|SYT9]]|0.43|
|[[:human genes:n:nop16|NOP16]]|0.43|
|[[:human genes:a:aqr|AQR]]|0.427|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.427|
|[[:human genes:s:ssh2|SSH2]]|0.426|
|[[:human genes:c:copg1|COPG1]]|0.426|
|[[:human genes:c:copb1|COPB1]]|0.425|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.423|
|[[:human genes:r:rrp7a|RRP7A]]|0.422|
|[[:human genes:r:rps2|RPS2]]|0.422|
|[[:human genes:r:rpl34|RPL34]]|0.421|
|[[:human genes:l:lrr1|LRR1]]|0.42|
|[[:human genes:m:med14|MED14]]|0.419|
|[[:human genes:s:snrpa1|SNRPA1]]|0.419|
|[[:human genes:d:disp2|DISP2]]|0.418|
|[[:human genes:p:psma7|PSMA7]]|0.417|
|[[:human genes:f:fam160a1|FAM160A1]]|0.416|
|[[:human genes:p:ppfia4|PPFIA4]]|0.415|
|[[:human genes:r:riok2|RIOK2]]|0.414|
|[[:human genes:n:nupl1|NUPL1]]|0.414|
|[[:human genes:p:psmb1|PSMB1]]|0.413|
|[[:human genes:t:ticrr|TICRR]]|0.412|
|[[:human genes:d:dtl|DTL]]|0.412|
|[[:human genes:c:ctr9|CTR9]]|0.411|
|[[:human genes:a:aamp|AAMP]]|0.411|
|[[:human genes:s:sult1a3|SULT1A3]]|0.411|
|[[:human genes:s:sult1a4|SULT1A4]]|0.41|
|[[:human genes:r:rps7|RPS7]]|0.406|
|[[:human genes:a:atp1a3|ATP1A3]]|0.406|
|[[:human genes:o:orc1|ORC1]]|0.406|
|[[:human genes:c:ccdc94|CCDC94]]|0.405|
|[[:human genes:n:narfl|NARFL]]|0.404|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.403|
|[[:human genes:p:pola1|POLA1]]|0.402|
|[[:human genes:c:cactin|CACTIN]]|0.402|
|[[:human genes:r:rps12|RPS12]]|0.402|
|[[:human genes:s:sel1l|SEL1L]]|0.401|
|[[:human genes:r:rps19|RPS19]]|0.4|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2128
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FCN2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>