FDXR [The Human Chemical-Genetic Interaction Map Project]

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======= FDXR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FDXR
  * **<color #00a2e8>Official Name</color>**: ferredoxin reductase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2232|2232]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22570|P22570]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FDXR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FDXR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/103270|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ferredoxin-NADP+ reductase activity|
|NADPH-adrenodoxin reductase activity|
|C21-steroid hormone biosynthetic process|
|quinone biosynthetic process|
|ubiquinone biosynthetic process|
|ubiquinone metabolic process|
|ketone biosynthetic process|
|C21-steroid hormone metabolic process|
|quinone metabolic process|
|steroid hormone biosynthetic process|
|oxidoreduction coenzyme metabolic process|
|hormone biosynthetic process|
|cellular ketone metabolic process|
|cholesterol metabolic process|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|coenzyme biosynthetic process|
|hormone metabolic process|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|steroid metabolic process|
|alcohol metabolic process|
|mitochondrial matrix|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|regulation of hormone levels|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|oxidation-reduction process|
|lipid metabolic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.32|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.7|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.72|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.81|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.91|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.475|
|[[:human genes:h:hscb|HSCB]]|0.467|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 227/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|5/28|
|bone|9/26|
|breast|7/33|
|central nervous system|26/56|
|cervix|2/4|
|colorectal|5/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|8/21|
|liver|8/20|
|lung|24/75|
|lymphocyte|4/16|
|ovary|8/26|
|pancreas|10/24|
|peripheral nervous system|6/16|
|plasma cell|6/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|3/9|
|thyroid|2/2|
|upper aerodigestive|10/22|
|urinary tract|14/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 206
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FDXR Expression in NALM6 Cells: 3.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>