FER1L5 [The Human Chemical-Genetic Interaction Map Project]

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======= FER1L5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FER1L5
  * **<color #00a2e8>Official Name</color>**: fer-1 like family member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90342|90342]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A0AVI2|A0AVI2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FER1L5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FER1L5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620883|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FerB|
|FerI|
|C2|
|FerA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myoblast fusion|
|cell-cell fusion|
|syncytium formation by plasma membrane fusion|
|syncytium formation|
|myotube differentiation|
|striated muscle cell differentiation|
|muscle cell differentiation|
|muscle structure development|
|anatomical structure formation involved in morphogenesis|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.81|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.95|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13116
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FER1L5 Expression in NALM6 Cells: 2.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>