FFAR1 [The Human Chemical-Genetic Interaction Map Project]

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======= FFAR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FFAR1
  * **<color #00a2e8>Official Name</color>**: free fatty acid receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2864|2864]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14842|O14842]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FFAR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FFAR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603820|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. {ECO:0000250|UniProtKB:Q76JU9, ECO:0000269|PubMed:12496284, ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:24130766}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|bioactive lipid receptor activity|
|insulin secretion|
|peptide hormone secretion|
|hormone secretion|
|positive regulation of insulin secretion|
|hormone transport|
|response to fatty acid|
|positive regulation of peptide hormone secretion|
|positive regulation of calcium ion transport|
|positive regulation of hormone secretion|
|lipid binding|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|signal release|
|peptide secretion|
|regulation of insulin secretion|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of peptide hormone secretion|
|regulation of calcium ion transport|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of ion transport|
|positive regulation of peptide secretion|
|response to acid chemical|
|regulation of metal ion transport|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of hormone levels|
|regulation of ion transport|
|regulation of protein transport|
|G protein-coupled receptor activity|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|response to lipid|
|positive regulation of transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-1.98|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.93|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.82|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16059
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FFAR1 Expression in NALM6 Cells: 1.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>