FGF16 [The Human Chemical-Genetic Interaction Map Project]

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======= FGF16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGF16
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor 16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8823|8823]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43320|O43320]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGF16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGF16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300827|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. {ECO:0000269|PubMed:16597617}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of brown fat cell proliferation|
|regulation of brown fat cell proliferation|
|positive regulation of cell chemotaxis to fibroblast growth factor|
|positive regulation of endothelial cell chemotaxis to fibroblast growth factor|
|positive regulation of fat cell proliferation|
|regulation of endothelial cell chemotaxis to fibroblast growth factor|
|regulation of cell chemotaxis to fibroblast growth factor|
|regulation of fat cell proliferation|
|positive regulation of endothelial cell chemotaxis|
|fibroblast growth factor receptor binding|
|regulation of endothelial cell chemotaxis|
|regulation of sprouting angiogenesis|
|fibroblast growth factor receptor signaling pathway|
|positive regulation of endothelial cell migration|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|regulation of endothelial cell proliferation|
|positive regulation of chemotaxis|
|positive regulation of epithelial cell migration|
|regulation of endothelial cell migration|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|response to temperature stimulus|
|regulation of chemotaxis|
|regulation of protein kinase B signaling|
|regulation of epithelial cell migration|
|regulation of cellular response to growth factor stimulus|
|regulation of angiogenesis|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|regulation of MAP kinase activity|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|positive regulation of response to external stimulus|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of intracellular signal transduction|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|cell-cell signaling|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|phosphorylation|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of phosphorylation|
|extracellular space|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.481|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15513
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGF16 Expression in NALM6 Cells: -5.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>