FGF23 [The Human Chemical-Genetic Interaction Map Project]

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======= FGF23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGF23
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor 23
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8074|8074]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZV9|Q9GZV9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGF23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGF23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605380|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. {ECO:0000250, ECO:0000269|PubMed:11062477, ECO:0000269|PubMed:11409890, ECO:0000269|PubMed:15040831, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18282132}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to sodium phosphate|
|vitamin D catabolic process|
|regulation of vitamin D 24-hydroxylase activity|
|positive regulation of vitamin D 24-hydroxylase activity|
|type 1 fibroblast growth factor receptor binding|
|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway|
|cellular phosphate ion homeostasis|
|cellular trivalent inorganic anion homeostasis|
|regulation of phosphate transport|
|cellular divalent inorganic anion homeostasis|
|fat-soluble vitamin catabolic process|
|cellular response to parathyroid hormone stimulus|
|cellular anion homeostasis|
|trivalent inorganic anion homeostasis|
|response to parathyroid hormone|
|phosphate ion homeostasis|
|cellular monovalent inorganic anion homeostasis|
|divalent inorganic anion homeostasis|
|vitamin catabolic process|
|vitamin D metabolic process|
|cellular response to vitamin D|
|cellular response to leptin stimulus|
|negative regulation of bone mineralization|
|response to salt|
|response to magnesium ion|
|response to leptin|
|cellular response to vitamin|
|monovalent inorganic anion homeostasis|
|steroid catabolic process|
|negative regulation of biomineralization|
|negative regulation of biomineral tissue development|
|response to vitamin D|
|cellular response to interleukin-6|
|fat-soluble vitamin metabolic process|
|response to interleukin-6|
|negative regulation of osteoblast differentiation|
|positive regulation of oxidoreductase activity|
|anion homeostasis|
|negative regulation of hormone secretion|
|cellular response to nutrient|
|negative regulation of ossification|
|regulation of bone mineralization|
|organic hydroxy compound catabolic process|
|fibroblast growth factor receptor signaling pathway|
|response to vitamin|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|regulation of anion transport|
|regulation of oxidoreductase activity|
|Golgi lumen|
|cellular response to fibroblast growth factor stimulus|
|regulation of osteoblast differentiation|
|response to fibroblast growth factor|
|vitamin metabolic process|
|growth factor activity|
|positive regulation of protein kinase B signaling|
|regulation of ossification|
|negative regulation of secretion by cell|
|positive regulation of ERK1 and ERK2 cascade|
|response to nutrient|
|regulation of protein kinase B signaling|
|negative regulation of secretion|
|cellular response to nutrient levels|
|steroid metabolic process|
|cellular response to extracellular stimulus|
|regulation of hormone secretion|
|regulation of ERK1 and ERK2 cascade|
|lipid catabolic process|
|endoplasmic reticulum lumen|
|cellular response to external stimulus|
|post-translational protein modification|
|response to metal ion|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|negative regulation of transport|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cellular response to lipid|
|response to growth factor|
|response to extracellular stimulus|
|response to inorganic substance|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|cellular response to hormone stimulus|
|cellular ion homeostasis|
|regulation of ion transport|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|ion homeostasis|
|regulation of secretion|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|negative regulation of developmental process|
|protein phosphorylation|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to cytokine|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.89|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.75|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.82|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15440
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGF23 Expression in NALM6 Cells: 0.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>