FGFRL1 [The Human Chemical-Genetic Interaction Map Project]

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======= FGFRL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGFRL1
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor receptor like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=53834|53834]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N441|Q8N441]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGFRL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGFRL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605830|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has a negative effect on cell proliferation. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ig|
|V-set|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fibroblast growth factor-activated receptor activity|
|diaphragm development|
|cell-cell contact zone|
|fibroblast growth factor binding|
|ventricular septum morphogenesis|
|substrate adhesion-dependent cell spreading|
|heart valve morphogenesis|
|heart valve development|
|ventricular septum development|
|cardiac septum morphogenesis|
|fibroblast growth factor receptor signaling pathway|
|transport vesicle|
|protein heterooligomerization|
|cellular response to fibroblast growth factor stimulus|
|cardiac septum development|
|response to fibroblast growth factor|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|skeletal muscle organ development|
|cardiac chamber development|
|heparin binding|
|cell-substrate adhesion|
|respiratory system development|
|heart morphogenesis|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|muscle organ development|
|protein homooligomerization|
|muscle structure development|
|skeletal system development|
|cellular response to growth factor stimulus|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|protein complex oligomerization|
|heart development|
|response to growth factor|
|cell morphogenesis involved in differentiation|
|negative regulation of cell population proliferation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|cellular component morphogenesis|
|circulatory system development|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|Golgi apparatus|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|cell development|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.451|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15049
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGFRL1 Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>