FH [The Human Chemical-Genetic Interaction Map Project]

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======= FH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FH
  * **<color #00a2e8>Official Name</color>**: fumarate hydratase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2271|2271]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07954|P07954]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/136850|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Also acts as a tumor suppressor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lyase 1|
|FumaraseC C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tricarboxylic acid cycle enzyme complex|
|fumarate hydratase activity|
|fumarate metabolic process|
|malate metabolic process|
|homeostasis of number of cells within a tissue|
|tricarboxylic acid cycle|
|aerobic respiration|
|dicarboxylic acid metabolic process|
|positive regulation of cold-induced thermogenesis|
|chromosome|
|regulation of cold-induced thermogenesis|
|cellular respiration|
|tissue homeostasis|
|homeostasis of number of cells|
|energy derivation by oxidation of organic compounds|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|homeostatic process|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.17|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-2.15|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.03|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.98|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.98|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-1.97|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.96|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.89|
|[[:results:exp303|39°C R06 exp303]]|-1.88|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.81|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.81|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.81|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.81|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.78|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.74|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.73|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.76|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.83|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.83|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.84|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.9|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.96|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.98|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.06|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.23|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.627|
|[[:human genes:l:lsm10|LSM10]]|0.602|
|[[:human genes:a:atxn10|ATXN10]]|0.581|
|[[:human genes:p:ppp6c|PPP6C]]|0.574|
|[[:human genes:r:rpia|RPIA]]|0.57|
|[[:human genes:b:bcs1l|BCS1L]]|0.557|
|[[:human genes:u:uhrf1|UHRF1]]|0.554|
|[[:human genes:t:tmem242|TMEM242]]|0.554|
|[[:human genes:g:gemin7|GEMIN7]]|0.554|
|[[:human genes:v:vezt|VEZT]]|0.552|
|[[:human genes:a:atic|ATIC]]|0.552|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.548|
|[[:human genes:r:rft1|RFT1]]|0.546|
|[[:human genes:a:atp5b|ATP5B]]|0.545|
|[[:human genes:d:dars2|DARS2]]|0.541|
|[[:human genes:y:yars2|YARS2]]|0.539|
|[[:human genes:d:dhrsx|DHRSX]]|0.539|
|[[:human genes:g:gemin8|GEMIN8]]|0.538|
|[[:human genes:t:tpk1|TPK1]]|0.538|
|[[:human genes:t:trmt61a|TRMT61A]]|0.538|
|[[:human genes:p:ppcs|PPCS]]|0.537|
|[[:human genes:d:dnlz|DNLZ]]|0.532|
|[[:human genes:c:c17orf89|C17orf89]]|0.532|
|[[:human genes:m:mrpl21|MRPL21]]|0.531|
|[[:human genes:a:atp5o|ATP5O]]|0.531|
|[[:human genes:p:pgm3|PGM3]]|0.531|
|[[:human genes:d:dpagt1|DPAGT1]]|0.529|
|[[:human genes:s:slc25a26|SLC25A26]]|0.528|
|[[:human genes:u:uap1|UAP1]]|0.527|
|[[:human genes:a:atp5a1|ATP5A1]]|0.527|
|[[:human genes:d:ddx1|DDX1]]|0.527|
|[[:human genes:p:pmvk|PMVK]]|0.524|
|[[:human genes:r:rpp21|RPP21]]|0.522|
|[[:human genes:g:gemin6|GEMIN6]]|0.522|
|[[:human genes:m:mrps21|MRPS21]]|0.518|
|[[:human genes:d:dolk|DOLK]]|0.517|
|[[:human genes:a:alg1|ALG1]]|0.516|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.515|
|[[:human genes:t:triap1|TRIAP1]]|0.513|
|[[:human genes:p:pmm2|PMM2]]|0.513|
|[[:human genes:s:srp14|SRP14]]|0.51|
|[[:human genes:a:atp5d|ATP5D]]|0.508|
|[[:human genes:p:ppcdc|PPCDC]]|0.506|
|[[:human genes:z:zcrb1|ZCRB1]]|0.505|
|[[:human genes:d:ddx39a|DDX39A]]|0.5|
|[[:human genes:p:ppa1|PPA1]]|0.499|
|[[:human genes:r:rabggtb|RABGGTB]]|0.499|
|[[:human genes:p:ppa2|PPA2]]|0.499|
|[[:human genes:s:slc25a19|SLC25A19]]|0.498|
|[[:human genes:m:mrps6|MRPS6]]|0.497|
|[[:human genes:d:dap3|DAP3]]|0.494|
|[[:human genes:r:rfk|RFK]]|0.493|
|[[:human genes:t:tars2|TARS2]]|0.492|
|[[:human genes:m:mrps16|MRPS16]]|0.49|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.489|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.486|
|[[:human genes:d:dohh|DOHH]]|0.483|
|[[:human genes:n:nars2|NARS2]]|0.483|
|[[:human genes:l:lars2|LARS2]]|0.48|
|[[:human genes:s:sco2|SCO2]]|0.479|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.479|
|[[:human genes:m:mrps5|MRPS5]]|0.479|
|[[:human genes:e:elp2|ELP2]]|0.478|
|[[:human genes:t:trmt5|TRMT5]]|0.478|
|[[:human genes:s:srd5a3|SRD5A3]]|0.477|
|[[:human genes:s:selrc1|SELRC1]]|0.477|
|[[:human genes:m:mrps14|MRPS14]]|0.476|
|[[:human genes:a:atp5j|ATP5J]]|0.475|
|[[:human genes:a:adsl|ADSL]]|0.475|
|[[:human genes:p:ppp4c|PPP4C]]|0.474|
|[[:human genes:z:zrsr2|ZRSR2]]|0.474|
|[[:human genes:d:dr1|DR1]]|0.473|
|[[:human genes:r:rbfa|RBFA]]|0.472|
|[[:human genes:m:mrpl53|MRPL53]]|0.472|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.471|
|[[:human genes:a:atp5h|ATP5H]]|0.469|
|[[:human genes:q:qrsl1|QRSL1]]|0.469|
|[[:human genes:e:elp6|ELP6]]|0.468|
|[[:human genes:g:gatc|GATC]]|0.468|
|[[:human genes:p:pars2|PARS2]]|0.468|
|[[:human genes:c:chchd4|CHCHD4]]|0.467|
|[[:human genes:c:c15orf41|C15orf41]]|0.466|
|[[:human genes:e:ears2|EARS2]]|0.466|
|[[:human genes:u:urm1|URM1]]|0.464|
|[[:human genes:s:ssb|SSB]]|0.463|
|[[:human genes:m:mrps26|MRPS26]]|0.463|
|[[:human genes:g:g6pd|G6PD]]|0.461|
|[[:human genes:t:tsen54|TSEN54]]|0.461|
|[[:human genes:m:mrp63|MRP63]]|0.46|
|[[:human genes:m:med16|MED16]]|0.46|
|[[:human genes:a:atp5c1|ATP5C1]]|0.457|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.457|
|[[:human genes:r:rtcb|RTCB]]|0.456|
|[[:human genes:c:cox16|COX16]]|0.456|
|[[:human genes:m:mrpl23|MRPL23]]|0.455|
|[[:human genes:t:ttc4|TTC4]]|0.455|
|[[:human genes:a:alg6|ALG6]]|0.454|
|[[:human genes:c:cxorf56|CXorf56]]|0.454|
|[[:human genes:k:kdsr|KDSR]]|0.451|
|[[:human genes:e:elac2|ELAC2]]|0.45|
|[[:human genes:p:pdss1|PDSS1]]|0.45|
|[[:human genes:h:hars2|HARS2]]|0.449|
|[[:human genes:m:mrps34|MRPS34]]|0.448|
|[[:human genes:u:ube2m|UBE2M]]|0.448|
|[[:human genes:c:cox7b|COX7B]]|0.447|
|[[:human genes:e:exoc4|EXOC4]]|0.446|
|[[:human genes:e:elp3|ELP3]]|0.444|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.441|
|[[:human genes:r:romo1|ROMO1]]|0.441|
|[[:human genes:f:fen1|FEN1]]|0.44|
|[[:human genes:t:tomm22|TOMM22]]|0.44|
|[[:human genes:l:lsm11|LSM11]]|0.439|
|[[:human genes:g:gfpt1|GFPT1]]|0.439|
|[[:human genes:m:mbtps2|MBTPS2]]|0.439|
|[[:human genes:p:ptar1|PTAR1]]|0.439|
|[[:human genes:m:mrps11|MRPS11]]|0.438|
|[[:human genes:r:rpusd4|RPUSD4]]|0.438|
|[[:human genes:t:trnt1|TRNT1]]|0.437|
|[[:human genes:t:ten1|TEN1]]|0.436|
|[[:human genes:m:mrps33|MRPS33]]|0.435|
|[[:human genes:g:gfm1|GFM1]]|0.435|
|[[:human genes:c:c11orf57|C11orf57]]|0.434|
|[[:human genes:c:c12orf65|C12orf65]]|0.434|
|[[:human genes:n:ndufb11|NDUFB11]]|0.433|
|[[:human genes:f:fastkd5|FASTKD5]]|0.433|
|[[:human genes:g:gmppb|GMPPB]]|0.432|
|[[:human genes:n:ndufb5|NDUFB5]]|0.43|
|[[:human genes:v:vhl|VHL]]|0.429|
|[[:human genes:m:mrpl47|MRPL47]]|0.428|
|[[:human genes:c:cox5a|COX5A]]|0.427|
|[[:human genes:n:nae1|NAE1]]|0.426|
|[[:human genes:c:ctc1|CTC1]]|0.425|
|[[:human genes:r:rptor|RPTOR]]|0.425|
|[[:human genes:w:wdr92|WDR92]]|0.425|
|[[:human genes:u:uba3|UBA3]]|0.424|
|[[:human genes:r:rars2|RARS2]]|0.424|
|[[:human genes:p:pdap1|PDAP1]]|0.424|
|[[:human genes:c:cbx3|CBX3]]|0.424|
|[[:human genes:s:sars2|SARS2]]|0.421|
|[[:human genes:m:med25|MED25]]|0.421|
|[[:human genes:g:gfm2|GFM2]]|0.42|
|[[:human genes:v:vars2|VARS2]]|0.419|
|[[:human genes:r:rpe|RPE]]|0.417|
|[[:human genes:a:atp5l|ATP5L]]|0.416|
|[[:human genes:m:mrps2|MRPS2]]|0.415|
|[[:human genes:k:kctd5|KCTD5]]|0.415|
|[[:human genes:t:trmt6|TRMT6]]|0.415|
|[[:human genes:t:txnrd1|TXNRD1]]|0.414|
|[[:human genes:d:ddx20|DDX20]]|0.413|
|[[:human genes:t:tbcb|TBCB]]|0.412|
|[[:human genes:s:sdha|SDHA]]|0.412|
|[[:human genes:u:ube2g2|UBE2G2]]|0.412|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.411|
|[[:human genes:p:pggt1b|PGGT1B]]|0.409|
|[[:human genes:t:tmem41b|TMEM41B]]|0.409|
|[[:human genes:n:n6amt1|N6AMT1]]|0.407|
|[[:human genes:p:pgs1|PGS1]]|0.407|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.407|
|[[:human genes:e:eef1e1|EEF1E1]]|0.405|
|[[:human genes:t:trmt10a|TRMT10A]]|0.405|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.404|
|[[:human genes:t:timm10|TIMM10]]|0.404|
|[[:human genes:s:snapc5|SNAPC5]]|0.401|
|[[:human genes:c:ciao1|CIAO1]]|0.401|
|[[:human genes:n:ndufb6|NDUFB6]]|0.401|
|[[:human genes:p:polg|POLG]]|0.4|
|[[:human genes:g:gclc|GCLC]]|0.4|
|[[:human genes:a:alg13|ALG13]]|0.4|
|[[:human genes:t:tufm|TUFM]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1232
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FH Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>