FIGNL1 [The Human Chemical-Genetic Interaction Map Project]

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======= FIGNL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FIGNL1
  * **<color #00a2e8>Official Name</color>**: fidgetin like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63979|63979]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PIW4|Q6PIW4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FIGNL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FIGNL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615383|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX- dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376). May play a role in the control of male meiosis dynamic (By similarity). {ECO:0000250|UniProtKB:Q8BPY9, ECO:0000269|PubMed:23754376}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA|
|Vps4 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|osteoblast proliferation|
|microtubule-severing ATPase activity|
|microtubule severing|
|nuclear chromosome|
|regulation of double-strand break repair via homologous recombination|
|male meiotic nuclear division|
|cytoplasmic microtubule organization|
|cellular response to ionizing radiation|
|regulation of double-strand break repair|
|hydrolase activity|
|negative regulation of intrinsic apoptotic signaling pathway|
|regulation of DNA recombination|
|regulation of DNA repair|
|osteoblast differentiation|
|response to ionizing radiation|
|meiotic nuclear division|
|regulation of intrinsic apoptotic signaling pathway|
|meiotic cell cycle process|
|cellular response to radiation|
|ATP metabolic process|
|magnesium ion binding|
|regulation of response to DNA damage stimulus|
|meiotic cell cycle|
|negative regulation of apoptotic signaling pathway|
|ATPase activity|
|ossification|
|nuclear division|
|organelle fission|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of DNA metabolic process|
|cellular process involved in reproduction in multicellular organism|
|regulation of apoptotic signaling pathway|
|response to radiation|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|negative regulation of intracellular signal transduction|
|cell population proliferation|
|male gamete generation|
|microtubule-based process|
|gamete generation|
|perinuclear region of cytoplasm|
|regulation of cellular response to stress|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|multi-organism reproductive process|
|negative regulation of cell death|
|cell cycle process|
|cytoskeleton organization|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of signal transduction|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|reproductive process|
|reproduction|
|regulation of response to stress|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-2.21|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.04|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.92|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.9|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2207
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FIGNL1 Expression in NALM6 Cells: 6.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>