FIGNL2 [The Human Chemical-Genetic Interaction Map Project]

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======= FIGNL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FIGNL2
  * **<color #00a2e8>Official Name</color>**: fidgetin like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=401720|401720]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A6NMB9|A6NMB9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FIGNL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FIGNL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620503|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule-severing ATPase activity|
|microtubule severing|
|regulation of double-strand break repair via homologous recombination|
|cytoplasmic microtubule organization|
|regulation of double-strand break repair|
|regulation of DNA recombination|
|regulation of DNA repair|
|regulation of response to DNA damage stimulus|
|ATPase activity|
|regulation of DNA metabolic process|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|microtubule-based process|
|regulation of cellular response to stress|
|cytoskeleton organization|
|regulation of response to stress|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.38|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.72|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.74|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.77|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13652
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: N/A 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FIGNL2 Expression in NALM6 Cells: N/A'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>