FIP1L1 [The Human Chemical-Genetic Interaction Map Project]

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======= FIP1L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FIP1L1
  * **<color #00a2e8>Official Name</color>**: factor interacting with PAPOLA and CPSF1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81608|81608]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UN15|Q6UN15]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FIP1L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FIP1L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607686|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fip1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pre-mRNA cleavage required for polyadenylation|
|mRNA cleavage involved in mRNA processing|
|mRNA cleavage and polyadenylation specificity factor complex|
|mRNA cleavage|
|mRNA polyadenylation|
|RNA polyadenylation|
|termination of RNA polymerase II transcription|
|DNA-templated transcription, termination|
|mRNA 3-end processing|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|RNA phosphodiester bond hydrolysis|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|nucleic acid phosphodiester bond hydrolysis|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|RNA processing|
|intracellular protein transport|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.15|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.86|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.82|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.8|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.79|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.75|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.84|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.02|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.71|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|2.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 267/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|9/28|
|blood|4/28|
|bone|10/26|
|breast|12/33|
|central nervous system|13/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|7/21|
|liver|5/20|
|lung|31/75|
|lymphocyte|6/16|
|ovary|11/26|
|pancreas|9/24|
|peripheral nervous system|11/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|5/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|7/22|
|urinary tract|14/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2474
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FIP1L1 Expression in NALM6 Cells: 6.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>