FKBP1A [The Human Chemical-Genetic Interaction Map Project]

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======= FKBP1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FKBP1A
  * **<color #00a2e8>Official Name</color>**: FKBP prolyl isomerase 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2280|2280]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62942|P62942]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FKBP1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FKBP1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/186945|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. {ECO:0000269|PubMed:16720724, ECO:0000269|PubMed:1696686, ECO:0000269|PubMed:1701173, ECO:0000269|PubMed:9233797}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FKBP C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|macrolide binding|
|extrinsic component of organelle membrane|
|cytoplasmic side of membrane|
|ryanodine receptor complex|
|terminal cisterna|
|SMAD protein complex assembly|
|FK506 binding|
|amyloid fibril formation|
|protein maturation by protein folding|
|type I transforming growth factor beta receptor binding|
|calcium channel inhibitor activity|
|negative regulation of ryanodine-sensitive calcium-release channel activity|
|heart trabecula formation|
|negative regulation of release of sequestered calcium ion into cytosol|
|activin binding|
|positive regulation of sequestering of calcium ion|
|negative regulation of calcium ion transport into cytosol|
|trabecula formation|
|regulation of activin receptor signaling pathway|
|regulation of ryanodine-sensitive calcium-release channel activity|
|negative regulation of calcium-mediated signaling|
|heart trabecula morphogenesis|
|regulation of amyloid precursor protein catabolic process|
|negative regulation of calcium ion transmembrane transporter activity|
|protein refolding|
|negative regulation of calcium ion transmembrane transport|
|de novo protein folding|
|transforming growth factor beta receptor binding|
|negative regulation of cation channel activity|
|sarcoplasmic reticulum|
|trabecula morphogenesis|
|protein peptidyl-prolyl isomerization|
|peptidyl-prolyl cis-trans isomerase activity|
|ventricular cardiac muscle tissue morphogenesis|
|SMAD binding|
|ventricular cardiac muscle tissue development|
|chaperone-mediated protein folding|
|negative regulation of calcium ion transport|
|peptidyl-proline modification|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|cardiac muscle tissue morphogenesis|
|negative regulation of ion transmembrane transporter activity|
|cardiac ventricle morphogenesis|
|regulation of release of sequestered calcium ion into cytosol|
|negative regulation of transporter activity|
|muscle tissue morphogenesis|
|negative regulation of cation transmembrane transport|
|muscle organ morphogenesis|
|regulation of calcium ion transmembrane transporter activity|
|positive regulation of protein binding|
|negative regulation of ion transmembrane transport|
|regulation of calcium-mediated signaling|
|regulation of calcium ion transport into cytosol|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|positive regulation of protein ubiquitination|
|negative regulation of transmembrane transport|
|regulation of phosphoprotein phosphatase activity|
|regulation of sequestering of calcium ion|
|ion channel binding|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|Z disc|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of protein dephosphorylation|
|negative regulation of ion transport|
|regulation of calcium ion transmembrane transport|
|cardiac muscle tissue development|
|cardiac chamber development|
|regulation of cation channel activity|
|regulation of phosphatase activity|
|positive regulation of binding|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|calcium ion transmembrane transport|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of protein ubiquitination|
|regulation of dephosphorylation|
|regulation of protein binding|
|protein maturation|
|regulation of protein modification by small protein conjugation or removal|
|protein folding|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|T cell activation|
|regulation of calcium ion transport|
|calcium ion transport|
|heart morphogenesis|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|striated muscle tissue development|
|muscle organ development|
|divalent metal ion transport|
|muscle tissue development|
|divalent inorganic cation transport|
|regulation of cation transmembrane transport|
|regulation of binding|
|lymphocyte activation|
|regulation of metal ion transport|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|muscle structure development|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|negative regulation of intracellular signal transduction|
|heart development|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|tissue morphogenesis|
|negative regulation of protein modification process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|enzyme linked receptor protein signaling pathway|
|negative regulation of catalytic activity|
|cation transport|
|cellular protein-containing complex assembly|
|circulatory system development|
|peptidyl-amino acid modification|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|leukocyte activation|
|ion transmembrane transport|
|animal organ morphogenesis|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cell activation|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|transmembrane transport|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.87|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.24|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|5.49|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|6.2|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|7.62|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|7.81|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|7.84|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|8.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cnot8|CNOT8]]|0.498|
|[[:human genes:y:ypel5|YPEL5]]|0.493|
|[[:human genes:f:fam122a|FAM122A]]|0.427|
|[[:human genes:w:wdr26|WDR26]]|0.422|
|[[:human genes:c:cnot2|CNOT2]]|0.418|
|[[:human genes:m:memo1|MEMO1]]|0.414|
|[[:human genes:b:btk|BTK]]|0.409|
|[[:human genes:u:ube2h|UBE2H]]|0.407|
|[[:human genes:c:cdk8|CDK8]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14916
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FKBP1A Expression in NALM6 Cells: 6.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>