FKBP1B [The Human Chemical-Genetic Interaction Map Project]

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======= FKBP1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FKBP1B
  * **<color #00a2e8>Official Name</color>**: FKBP prolyl isomerase 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2281|2281]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P68106|P68106]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FKBP1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FKBP1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600620|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FKBP C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cyclic nucleotide binding|
|ryanodine-sensitive calcium-release channel activity|
|positive regulation of axon regeneration|
|protein maturation by protein folding|
|positive regulation of neuron projection regeneration|
|neuronal action potential propagation|
|negative regulation of insulin secretion involved in cellular response to glucose stimulus|
|FK506 binding|
|action potential propagation|
|negative regulation of heart rate|
|negative regulation of ryanodine-sensitive calcium-release channel activity|
|response to vitamin E|
|calcium channel inhibitor activity|
|response to redox state|
|negative regulation of release of sequestered calcium ion into cytosol|
|positive regulation of sequestering of calcium ion|
|cell communication by electrical coupling involved in cardiac conduction|
|negative regulation of calcium ion transport into cytosol|
|cell communication by electrical coupling|
|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|
|calcium-mediated signaling using intracellular calcium source|
|calcium channel complex|
|negative regulation of heart contraction|
|regulation of axon regeneration|
|regulation of cardiac muscle contraction by calcium ion signaling|
|regulation of ryanodine-sensitive calcium-release channel activity|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|regulation of neuron projection regeneration|
|negative regulation of calcium-mediated signaling|
|sarcoplasmic reticulum membrane|
|negative regulation of blood circulation|
|negative regulation of calcium ion transmembrane transporter activity|
|protein refolding|
|negative regulation of insulin secretion|
|T cell proliferation|
|negative regulation of calcium ion transmembrane transport|
|insulin secretion|
|de novo protein folding|
|negative regulation of cation channel activity|
|cell communication involved in cardiac conduction|
|negative regulation of peptide hormone secretion|
|protein peptidyl-prolyl isomerization|
|peptidyl-prolyl cis-trans isomerase activity|
|smooth muscle contraction|
|release of sequestered calcium ion into cytosol|
|transmission of nerve impulse|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|negative regulation of sequestering of calcium ion|
|chaperone-mediated protein folding|
|peptide hormone secretion|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of calcium ion transport|
|peptidyl-proline modification|
|negative regulation of hormone secretion|
|positive regulation of response to wounding|
|negative regulation of protein dephosphorylation|
|calcium ion transmembrane import into cytosol|
|regulation of cardiac conduction|
|negative regulation of ion transmembrane transporter activity|
|hormone secretion|
|calcium ion transport into cytosol|
|regulation of cardiac muscle contraction|
|regulation of release of sequestered calcium ion into cytosol|
|negative regulation of transporter activity|
|hormone transport|
|negative regulation of cation transmembrane transport|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|response to vitamin|
|regulation of calcium ion transmembrane transporter activity|
|cytosolic calcium ion transport|
|regulation of striated muscle contraction|
|cardiac conduction|
|action potential|
|negative regulation of ion transmembrane transport|
|regulation of heart rate|
|regulation of calcium-mediated signaling|
|leukocyte proliferation|
|regulation of calcium ion transport into cytosol|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|negative regulation of transmembrane transport|
|regulation of phosphoprotein phosphatase activity|
|response to hydrogen peroxide|
|regulation of sequestering of calcium ion|
|ion channel binding|
|negative regulation of protein secretion|
|Z disc|
|multicellular organismal signaling|
|response to glucose|
|negative regulation of peptide secretion|
|regulation of protein dephosphorylation|
|response to hexose|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|negative regulation of ion transport|
|response to monosaccharide|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of muscle contraction|
|protein localization to extracellular region|
|regulation of response to wounding|
|signal release|
|response to carbohydrate|
|regulation of cation channel activity|
|peptide secretion|
|regulation of phosphatase activity|
|regulation of insulin secretion|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|response to reactive oxygen species|
|calcium ion transmembrane transport|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|regulation of dephosphorylation|
|response to nutrient|
|protein maturation|
|protein folding|
|negative regulation of secretion|
|T cell activation|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of calcium ion transport|
|calcium ion transport|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of hormone secretion|
|regulation of transporter activity|
|positive regulation of neuron projection development|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|divalent metal ion transport|
|muscle system process|
|divalent inorganic cation transport|
|response to antibiotic|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|signaling receptor binding|
|second-messenger-mediated signaling|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|lymphocyte activation|
|regulation of metal ion transport|
|response to oxidative stress|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|negative regulation of hydrolase activity|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|response to nutrient levels|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|response to extracellular stimulus|
|regulation of hormone levels|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell population proliferation|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of system process|
|negative regulation of protein modification process|
|positive regulation of response to external stimulus|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|cation homeostasis|
|regulation of protein transport|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of secretion|
|regulation of neurogenesis|
|cation transport|
|peptidyl-amino acid modification|
|cellular homeostasis|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|ion transmembrane transport|
|positive regulation of cell differentiation|
|secretion by cell|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cell activation|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|transmembrane transport|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|regulation of response to stress|
|protein transport|
|generation of neurons|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|system process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15942
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FKBP1B Expression in NALM6 Cells: -0.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>